Additional file 6 of The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease

Additional file 6: Sup Figure 6. Genetically encoding GluA2(R) in J20 mice does not prevent neuroinflammation. (a) Representative images and stereological quantification revealed no changes were observed in the population of GFAP+ astrocytes within the CA1 and CA3 hippocampal regions (CA1 ANOVA F(3,16) = 0.39 p = 0.76 and CA3 ANOVA F(3,16) = 2.27 p = 0.12; n = 5/genotype). (b) Representative images and stereological quantification of CD68+ microglia in the hippocampus demonstrated a significant increase in both J20 and GluA2G/G/J20 animals when compared to WT and GluA2G/G mice (Kruskal-Wallis = 21.52 p