Additional file 8 of The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease

Additional file 8: Sup Figure 8. Behavioural assessment. (a-c) The total number of arm entries made in the Y-maze (a) as well as the time spent exploring the novel object in the recognition task (b) and the total time spent in the working memory version of the RAM (c) was not different between any of the genotypes indicating that hyperactivity did not affect animals’ ability to perform in these tests (n’s for a: WT = 24, GluA2G/G = 20, J20 = 24, GluA2G/G/J20 = 22; n’s for b: WT = 25, GluA2G/G = 21, J20 = 28, GluA2G/G/J20 = 22; n’s for c: WT = 14, GluA2G/G = 10, J20 = 10, GluA2G/G/J20 = 11; Y-maze entries ANOVA: F(3,8) = 2.271, p = 0.09; Object Recognition ANOVA: F(3,92) = 0.754, p = 0.52; RAM total time two-way RM ANOVA: genotype effect F(3,41) = 1.907, p = 0.14). (d) Total distance travelled in the open field test revealed both J20 and GluA2G/G/J20 mice displayed significantly more hyperactivity than WT and GluA2G/G mice (ANOVA F(3,88) = 18.90, p