Personal profile
Biography
Tim Karl graduated from the Leipniz University of Hanover (Germany) in 2003 with a PhD in Zoology (Behavioural Neuroscience). From 2004-2008, he was a postdoctoral researcher at the Garvan Institute of Medical Research working on rodent models for anxiety and schizophrenia, before establishing his own research team at Neuroscience Research Australia (NeuRA) in 2008. At NeuRA, his research focused on the neuro-behavioural consequences of gene-environment interactions in animal models for schizophrenia and the discovery of new therapeutic targets for dementia. In 2016, Tim Karl moved to Western Sydney University, where he continues his preclinical research into schizophrenia and neurodegenerative diseases. His team also evaluates both detrimental and beneficial effects of cannabis constituents on brain disorders. Finally, Prof Karl’s research aims to enhance the validity of rodent models and the well-being of test animals in medical research by improving laboratory housing and handling conditions and establishing more natural test paradigms.
Prof Karl’s team is currently funded by the National Health and Medical Research Council, NSW Health, FightMND, and the Ainsworth Medical Research Innovation Fund. The team also receives funding from industry partners.
Prof Karl is the Deputy Chair of the Animal Care and Ethics Committee at Western Sydney University and the NSW Department of Primary Industries Animal Research Review Panel.
Related links
Qualifications
Doctor of Natural Sciences
Research keywords
- Animal model
- Behaviour
- Alzheimer's disease
- Motor neuron disease
- Schizophrenia
- Cannabis
- Neuroscience
- Pharmacology
- Mouse
- Animal welfare
- Preclinical treatment evaluation
- Gene-environment interactions
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 9 Industry, Innovation, and Infrastructure
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Collaborations and top research areas from the last five years
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Cannabidiol (CBD) does not reduce cocaine reward or self-administration in a mouse model of schizophrenia genetic susceptibility
Chesworth, R., Watt, G., McLemon, E. & Karl, T., 2 Apr 2026, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 146, 10 p., 111676.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Cannabidiol modulates brain copper homeostasis in wild-type-like but not Alzheimer’s disease transgenic female mice: implications for neuroprotective therapy
Dosseto, A., Tonge, K. & Karl, T., Jan 2026, In: Molecular Neurobiology. 63, 1, 11 p., 57.Research output: Contribution to journal › Article › peer-review
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Combining cannabidiol and delta-9-tetrahydrocannabinol at a 50:3 ratio: a new therapeutic strategy for APPSwe/PS1ΔE9 transgenic mice?
Coles, M., Rosa Porto, R., Chesworth, R., Steiner-Lim, G. Z. & Karl, T., Aug 2026, In: Neurobiology of Aging. 164, p. 79-90 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Effects of chronic 100 mg/kg cannabidiol treatment in male double transgenic APPSwe/PS1∆E9 mice
Watt, G., Olaya, J., Muench, G., Garner, B. & Karl, T., Mar 2026, In: Pharmaceuticals. 19, 3, 17 p., 374.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Genetic risk for schizophrenia modulates WIN 55,212-2 reward: Evidence from a heterozygous transmembrane domain neuregulin 1 mutant mouse model
Chesworth, R., Watt, G., Howard, J., Ding, G. & Karl, T., 2026, (E-pub ahead of print (In Press)) In: Psychpharmacology.Research output: Contribution to journal › Article › peer-review
Open Access
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Developing novel strategies to normalize dopamine dysregulation during inflammation [via University of New South Wales]
Karl, T. (PI) & Vieyra, R. C. (Investigator)
6/02/23 → 31/12/26
Project: Research
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A novel cannabis formulation therapeutic strategy for early-stage Alzheimers disease
Steiner-Lim, G. (PI) & Karl, T. (Investigator)
Australian Natural Therapeutics Group Pty Ltd
19/12/19 → 31/12/26
Project: Research
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Modulating actin dynamics in ALS/MND as a novel therapeutic approach in ALS (Via Macquarie University)
Karl, T. (PI)
4/01/21 → 20/12/25
Project: Research
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Targeting the synaptic actin cytoskeleton in Alzheimer's Disease [via UNSW]
Karl, T. (PI)
National Health and Medical Research Council
28/03/18 → 31/12/18
Project: Research
Datasets
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IMMP2L Mouse Model Phenotyping
Kreilaus, F., Chesworth Vieyra, R., Eapen, V., Clarke, R. & Karl, T., Western Sydney University, 20 Feb 2025
DOI: 10.26183/mkk5-0j38, https://research-data.westernsydney.edu.au/published/b3acf0c0ef1211ef932c89d13fd01544
Dataset
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Cocaine + Cannabidiol effects on the gut microbiome
Chesworth, R. & Karl, T., Western Sydney University, 2024
DOI: 10.26183/6n4x-5n66, https://research-data.westernsydney.edu.au/published/93af7ce0217011efaff629844ac91e00
Dataset
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Higher Research Degree Annual Review Panel (Event)
Karl, T. (Member)
2022 → …Activity: Membership › Committee
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Ainsworth Medical Research Innovation Fund Steering Committee (Event)
Karl, T. (Chair)
2021 → 2023Activity: Membership › Committee
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