中药复方塞络通中银杏内酯类成分的药代动力学及脑分布研究

Translated title of the contribution: Pharmacokinetics and brain distribution of ginkgolides after administration of Sai-Luo-Tong

Ying Zhang, Li Lin, Changying Ren, Chengren Lin, Jianxun Liu, Dennis Chang, Alan Bensoussan

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Sai-Luo-Tong (SLT) is a compound preparation composed of ginseng, ginkgo and saffron for the treatment of vascular dementia. In order to identify its material foundation and provide evidence for therapeutic regimen, the plasma concentration, pharmacokinetics and brain distribution of ginkgolides were investigated after intragastric ad-ministration of SLT. An LC-MS/MS method was developed for the determination of 4 ginkgolides in rat plasma and brain simultaneously. Statistical analysis of obtained data demonstrated that the method had achieved the desired lin-earity, precision, accuracy and sensitivity. The results showed that after administration of SLT at the dose of 60 mg·kg-1, 4 ginkgolides were all absorbed into systemic circulation with AUC value in the order of bilobalide B (BB) >ginkgolide A (GA) > ginkgolide B (GB) > ginkgolide C (GC). All ginkgolides exhibited short half lives less than 2.8 hamong which BB showed the shortest t1/2 of 1.61 h. The determination of brain distribution at different time after dos-ing revealed ginkgolides entered into brain promptly dominated by GA and BB. The concentrations of 4 ginkgolidesin brain were much lower than these in plasma and declined along with time rapidly. It was concluded thatginkgolides can be absorbed in blood and penetrated into brain rapidly. GA, BB and GB might be main components which effect both periphery and brain collectively by means of their specific mechanism to achieve the therapeutic efficacy on vascular dementia of SLT.
    Translated title of the contributionPharmacokinetics and brain distribution of ginkgolides after administration of Sai-Luo-Tong
    Original languageChinese (Simplified)
    Pages (from-to)1458-1464
    Number of pages7
    JournalModernization of Traditional Chinese Medicine and Materia Medica
    Volume16
    Issue number7
    DOIs
    Publication statusPublished - 2014

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