A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection

M. Menti-Platten; J.R. Aldrich-Wright; C.P. Gordon

doi:10.1039/d1ob02179f

A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection

M. Menti-Platten
, J.R. Aldrich-Wright
, C.P. Gordon

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Orthogonal deprotection methodologies are an invaluable tool for the construction of site-specially modified peptides. Here, we report a facile 10% Pd/CaCO₃-based procedure to selectively mediate Nβ-side-chain Cbz-lysis from extended peptide sequences in the presence of trityl andt-Butyl protecting groups.

Original language	English
Pages (from-to)	106-112
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	20
Issue number	1
DOIs	https://doi.org/10.1039/d1ob02179f
Publication status	Published - 7 Jan 2022

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Publisher Copyright:
© The Royal Society of Chemistry 2021.

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10.1039/d1ob02179f

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abstract = "Orthogonal deprotection methodologies are an invaluable tool for the construction of site-specially modified peptides. Here, we report a facile 10\% Pd/CaCO3-based procedure to selectively mediate Nβ-side-chain Cbz-lysis from extended peptide sequences in the presence of trityl andt-Butyl protecting groups.",

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AU - Menti-Platten, M.

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AU - Gordon, C.P.

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N2 - Orthogonal deprotection methodologies are an invaluable tool for the construction of site-specially modified peptides. Here, we report a facile 10% Pd/CaCO3-based procedure to selectively mediate Nβ-side-chain Cbz-lysis from extended peptide sequences in the presence of trityl andt-Butyl protecting groups.

AB - Orthogonal deprotection methodologies are an invaluable tool for the construction of site-specially modified peptides. Here, we report a facile 10% Pd/CaCO3-based procedure to selectively mediate Nβ-side-chain Cbz-lysis from extended peptide sequences in the presence of trityl andt-Butyl protecting groups.

UR - https://hdl.handle.net/1959.7/uws:66700

U2 - 10.1039/d1ob02179f

DO - 10.1039/d1ob02179f

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A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection

Abstract

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