A flow chemistry approach to norcantharidin analogues

Mark Tarleton, Kelly A. Young, Eli Unicomb, Siobhann N. McCluskey, Mark J. Robertson, Christopher P. Gordon, Adam McCluskey

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Acid-ester and acid-amide norcantharidin derivatives are prepared using a 'one-pot' synthetic procedure utilizing the ThalesNano H-cube™ flow hydrogenator. Traditionally, rapid library generation and reaction scale up of these analogues was limited by the batch wise hydrogenation of 5,6-dehydronorcantharidin. This was resolved with the use of flow chemistry. With no associated scale up issues, a method was devised to produce norcantharidin, along with acid-ester and acid-amide analogues on any scale necessary for biological screening.
    Original languageEnglish
    Pages (from-to)568-574
    Number of pages7
    JournalLetters in Drug Design and Discovery
    Volume8
    Issue number6
    DOIs
    Publication statusPublished - 2011

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