TY - JOUR
T1 - A flow chemistry approach to norcantharidin analogues
AU - Tarleton, Mark
AU - Young, Kelly A.
AU - Unicomb, Eli
AU - McCluskey, Siobhann N.
AU - Robertson, Mark J.
AU - Gordon, Christopher P.
AU - McCluskey, Adam
PY - 2011
Y1 - 2011
N2 - Acid-ester and acid-amide norcantharidin derivatives are prepared using a 'one-pot' synthetic procedure utilizing the ThalesNano H-cube™ flow hydrogenator. Traditionally, rapid library generation and reaction scale up of these analogues was limited by the batch wise hydrogenation of 5,6-dehydronorcantharidin. This was resolved with the use of flow chemistry. With no associated scale up issues, a method was devised to produce norcantharidin, along with acid-ester and acid-amide analogues on any scale necessary for biological screening.
AB - Acid-ester and acid-amide norcantharidin derivatives are prepared using a 'one-pot' synthetic procedure utilizing the ThalesNano H-cube™ flow hydrogenator. Traditionally, rapid library generation and reaction scale up of these analogues was limited by the batch wise hydrogenation of 5,6-dehydronorcantharidin. This was resolved with the use of flow chemistry. With no associated scale up issues, a method was devised to produce norcantharidin, along with acid-ester and acid-amide analogues on any scale necessary for biological screening.
UR - http://handle.uws.edu.au:8081/1959.7/548446
U2 - 10.2174/157018011795906730
DO - 10.2174/157018011795906730
M3 - Article
SN - 1570-1808
VL - 8
SP - 568
EP - 574
JO - Letters in Drug Design and Discovery
JF - Letters in Drug Design and Discovery
IS - 6
ER -