A flow chemistry approach to norcantharidin analogues

Mark Tarleton; Kelly A. Young; Eli Unicomb; Siobhann N. McCluskey; Mark J. Robertson; Christopher P. Gordon; Adam McCluskey

doi:10.2174/157018011795906730

A flow chemistry approach to norcantharidin analogues

Mark Tarleton
, Kelly A. Young
, Eli Unicomb
, Siobhann N. McCluskey
, Mark J. Robertson
, Christopher P. Gordon
, Adam McCluskey

School of Science

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Acid-ester and acid-amide norcantharidin derivatives are prepared using a 'one-pot' synthetic procedure utilizing the ThalesNano H-cubeâ„¢ flow hydrogenator. Traditionally, rapid library generation and reaction scale up of these analogues was limited by the batch wise hydrogenation of 5,6-dehydronorcantharidin. This was resolved with the use of flow chemistry. With no associated scale up issues, a method was devised to produce norcantharidin, along with acid-ester and acid-amide analogues on any scale necessary for biological screening.

Original language	English
Pages (from-to)	568-574
Number of pages	7
Journal	Letters in Drug Design and Discovery
Volume	8
Issue number	6
DOIs	https://doi.org/10.2174/157018011795906730
Publication status	Published - 2011

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abstract = "Acid-ester and acid-amide norcantharidin derivatives are prepared using a 'one-pot' synthetic procedure utilizing the ThalesNano H-cube{\^a}„¢ flow hydrogenator. Traditionally, rapid library generation and reaction scale up of these analogues was limited by the batch wise hydrogenation of 5,6-dehydronorcantharidin. This was resolved with the use of flow chemistry. With no associated scale up issues, a method was devised to produce norcantharidin, along with acid-ester and acid-amide analogues on any scale necessary for biological screening.",

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T1 - A flow chemistry approach to norcantharidin analogues

AU - Tarleton, Mark

AU - Young, Kelly A.

AU - Unicomb, Eli

AU - McCluskey, Siobhann N.

AU - Robertson, Mark J.

AU - Gordon, Christopher P.

AU - McCluskey, Adam

PY - 2011

Y1 - 2011

N2 - Acid-ester and acid-amide norcantharidin derivatives are prepared using a 'one-pot' synthetic procedure utilizing the ThalesNano H-cubeâ„¢ flow hydrogenator. Traditionally, rapid library generation and reaction scale up of these analogues was limited by the batch wise hydrogenation of 5,6-dehydronorcantharidin. This was resolved with the use of flow chemistry. With no associated scale up issues, a method was devised to produce norcantharidin, along with acid-ester and acid-amide analogues on any scale necessary for biological screening.

AB - Acid-ester and acid-amide norcantharidin derivatives are prepared using a 'one-pot' synthetic procedure utilizing the ThalesNano H-cubeâ„¢ flow hydrogenator. Traditionally, rapid library generation and reaction scale up of these analogues was limited by the batch wise hydrogenation of 5,6-dehydronorcantharidin. This was resolved with the use of flow chemistry. With no associated scale up issues, a method was devised to produce norcantharidin, along with acid-ester and acid-amide analogues on any scale necessary for biological screening.

UR - http://handle.uws.edu.au:8081/1959.7/548446

U2 - 10.2174/157018011795906730

DO - 10.2174/157018011795906730

M3 - Article

SN - 1570-1808

VL - 8

SP - 568

EP - 574

JO - Letters in Drug Design and Discovery

JF - Letters in Drug Design and Discovery

IS - 6

ER -

A flow chemistry approach to norcantharidin analogues

Abstract

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