A fluorine-18 radiolabeling method enabled by Rhenium(I) complexation circumvents the requirement of anhydrous conditions

Mitchell A. Klenner; Giancarlo Pascali; Bo Zhang; Tiffany R. Sia; Lawson K. Spare; Anwen M. Krause-Heuer; Janice R. Aldrich-Wright; Ivan Greguric; Adam J. Guastella; Massimiliano Massi; Benjamin H. Fraser

doi:10.1002/chem.201700440

A fluorine-18 radiolabeling method enabled by Rhenium(I) complexation circumvents the requirement of anhydrous conditions

Mitchell A. Klenner, Giancarlo Pascali, Bo Zhang, Tiffany R. Sia, Lawson K. Spare, Anwen M. Krause-Heuer, Janice R. Aldrich-Wright, Ivan Greguric, Adam J. Guastella, Massimiliano Massi, Benjamin H. Fraser

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes.

Original language	English
Pages (from-to)	6499-6503
Number of pages	5
Journal	Chemistry: A European Journal
Volume	23
Issue number	27
DOIs	https://doi.org/10.1002/chem.201700440
Publication status	Published - 2017

Keywords

azeotropic distillation
fluorination
radioactive decay
radiolabeling
rhenium compounds
tomography_emission

Access to Document

10.1002/chem.201700440

Cite this

Klenner, M. A., Pascali, G., Zhang, B., Sia, T. R., Spare, L. K., Krause-Heuer, A. M., Aldrich-Wright, J. R., Greguric, I., Guastella, A. J., Massi, M., & Fraser, B. H. (2017). A fluorine-18 radiolabeling method enabled by Rhenium(I) complexation circumvents the requirement of anhydrous conditions. Chemistry: A European Journal, 23(27), 6499-6503. https://doi.org/10.1002/chem.201700440

@article{e68521599367486fb813b9592a3dbf3c,

title = "A fluorine-18 radiolabeling method enabled by Rhenium(I) complexation circumvents the requirement of anhydrous conditions",

abstract = "Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes.",

keywords = "azeotropic distillation, fluorination, radioactive decay, radiolabeling, rhenium compounds, tomography_emission",

author = "Klenner, {Mitchell A.} and Giancarlo Pascali and Bo Zhang and Sia, {Tiffany R.} and Spare, {Lawson K.} and Krause-Heuer, {Anwen M.} and Aldrich-Wright, {Janice R.} and Ivan Greguric and Guastella, {Adam J.} and Massimiliano Massi and Fraser, {Benjamin H.}",

year = "2017",

doi = "10.1002/chem.201700440",

language = "English",

volume = "23",

pages = "6499--6503",

journal = "Chemistry: A European Journal",

issn = "0947-6539",

publisher = "Wiley & Sons",

number = "27",

}

Klenner, MA, Pascali, G, Zhang, B, Sia, TR, Spare, LK, Krause-Heuer, AM, Aldrich-Wright, JR, Greguric, I, Guastella, AJ, Massi, M & Fraser, BH 2017, 'A fluorine-18 radiolabeling method enabled by Rhenium(I) complexation circumvents the requirement of anhydrous conditions', Chemistry: A European Journal, vol. 23, no. 27, pp. 6499-6503. https://doi.org/10.1002/chem.201700440

TY - JOUR

T1 - A fluorine-18 radiolabeling method enabled by Rhenium(I) complexation circumvents the requirement of anhydrous conditions

AU - Klenner, Mitchell A.

AU - Pascali, Giancarlo

AU - Zhang, Bo

AU - Sia, Tiffany R.

AU - Spare, Lawson K.

AU - Krause-Heuer, Anwen M.

AU - Aldrich-Wright, Janice R.

AU - Greguric, Ivan

AU - Guastella, Adam J.

AU - Massi, Massimiliano

AU - Fraser, Benjamin H.

PY - 2017

Y1 - 2017

N2 - Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes.

AB - Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes.

KW - azeotropic distillation

KW - fluorination

KW - radioactive decay

KW - radiolabeling

KW - rhenium compounds

KW - tomography_emission

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:40480

U2 - 10.1002/chem.201700440

DO - 10.1002/chem.201700440

M3 - Article

SN - 0947-6539

VL - 23

SP - 6499

EP - 6503

JO - Chemistry: A European Journal

JF - Chemistry: A European Journal

IS - 27

ER -

A fluorine-18 radiolabeling method enabled by Rhenium(I) complexation circumvents the requirement of anhydrous conditions

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this