A model for predicting magnetic particle capture in a microfluidic bioseparator

E. P. Furlani, Y. Sahoo, K. C. Ng, J. C. Wortman, T. E. Monk

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)

Abstract

A model is presented for predicting the capture of magnetic micro/nano-particles in a bioseparation microsystem. This bioseparator consists of an array of conductive elements embedded beneath a rectangular microfluidic channel. The magnetic particles are introduced into the microchannel in solution, and are attracted and held by the magnetic force produced by the energized elements. Analytical expressions are obtained for the dominant magnetic and fluidic forces on the particles as they move through the microchannel. These expressions are included in the equations of motion, which are solved numerically to predict particle trajectories and capture time. This model is well-suited for parametric analysis of particle capture taking into account variations in particle size, material properties, applied current, microchannel dimensions, fluid properties, and flow velocity.
Original languageEnglish
Pages (from-to)451-463
Number of pages13
JournalBiomedical Microdevices
Volume9
Issue number4
DOIs
Publication statusPublished - 2007

Keywords

  • biomolecules
  • magnetic separation

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