A new biomarker for closed-loop deep brain stimulation in the subthalamic nucleus for patients with Parkinson's disease

Gerrit E. Gmel; John L. Parker; Tara J. Hamilton

doi:10.1109/BioCAS.2014.6981772

A new biomarker for closed-loop deep brain stimulation in the subthalamic nucleus for patients with Parkinson's disease

Gerrit E. Gmel
, John L. Parker
, Tara J. Hamilton

School of Engineering, Design & Built Environment

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

3 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) has become the standard treatment for advanced stages of Parkinson's disease and other motor disorders. Although the surgical procedure has gained in accuracy over the years thanks to imaging and microelectrode recordings, the underlying principles of DBS are still debated today. The lack of a clear measurable biomarker for the efficacy of the therapy has rendered efforts to design feedback-enabled stimulators difficult. Our most recent intra-operative recordings have unveiled a new biomarker based on stimulation induced evoked responses that could lead to a new approach to closing the loop and designing an adaptive deep brain stimulator.

Original language	English
Title of host publication	Proceedings IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014: Breakthrough for Distributed Diagnostics and Therapy: 22-24 October 2014, EPFL, Lausanne, Switzerland
Publisher	IEEE
Pages	500-503
Number of pages	4
ISBN (Print)	9781479923465
DOIs	https://doi.org/10.1109/BioCAS.2014.6981772
Publication status	Published - 2014
Event	IEEE Biomedical Circuits and Systems Conference - Duration: 22 Oct 2014 → …

Conference

Conference	IEEE Biomedical Circuits and Systems Conference
Period	22/10/14 → …

Keywords

Parkinson's disease
basal ganglia
biochemical markers
subthalamus

Access to Document

10.1109/BioCAS.2014.6981772

Cite this

Gmel, G. E., Parker, J. L., & Hamilton, T. J. (2014). A new biomarker for closed-loop deep brain stimulation in the subthalamic nucleus for patients with Parkinson's disease. In Proceedings IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014: Breakthrough for Distributed Diagnostics and Therapy: 22-24 October 2014, EPFL, Lausanne, Switzerland (pp. 500-503). IEEE. https://doi.org/10.1109/BioCAS.2014.6981772

Gmel, Gerrit E. ; Parker, John L. ; Hamilton, Tara J. / A new biomarker for closed-loop deep brain stimulation in the subthalamic nucleus for patients with Parkinson's disease. Proceedings IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014: Breakthrough for Distributed Diagnostics and Therapy: 22-24 October 2014, EPFL, Lausanne, Switzerland. IEEE, 2014. pp. 500-503

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title = "A new biomarker for closed-loop deep brain stimulation in the subthalamic nucleus for patients with Parkinson's disease",

abstract = "Deep brain stimulation (DBS) has become the standard treatment for advanced stages of Parkinson's disease and other motor disorders. Although the surgical procedure has gained in accuracy over the years thanks to imaging and microelectrode recordings, the underlying principles of DBS are still debated today. The lack of a clear measurable biomarker for the efficacy of the therapy has rendered efforts to design feedback-enabled stimulators difficult. Our most recent intra-operative recordings have unveiled a new biomarker based on stimulation induced evoked responses that could lead to a new approach to closing the loop and designing an adaptive deep brain stimulator.",

keywords = "Parkinson's disease, basal ganglia, biochemical markers, subthalamus",

author = "Gmel, \{Gerrit E.\} and Parker, \{John L.\} and Hamilton, \{Tara J.\}",

year = "2014",

doi = "10.1109/BioCAS.2014.6981772",

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booktitle = "Proceedings IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014: Breakthrough for Distributed Diagnostics and Therapy: 22-24 October 2014, EPFL, Lausanne, Switzerland",

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Gmel, GE, Parker, JL & Hamilton, TJ 2014, A new biomarker for closed-loop deep brain stimulation in the subthalamic nucleus for patients with Parkinson's disease. in Proceedings IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014: Breakthrough for Distributed Diagnostics and Therapy: 22-24 October 2014, EPFL, Lausanne, Switzerland. IEEE, pp. 500-503, IEEE Biomedical Circuits and Systems Conference, 22/10/14. https://doi.org/10.1109/BioCAS.2014.6981772

A new biomarker for closed-loop deep brain stimulation in the subthalamic nucleus for patients with Parkinson's disease. / Gmel, Gerrit E.; Parker, John L.; Hamilton, Tara J.
Proceedings IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014: Breakthrough for Distributed Diagnostics and Therapy: 22-24 October 2014, EPFL, Lausanne, Switzerland. IEEE, 2014. p. 500-503.

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

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AB - Deep brain stimulation (DBS) has become the standard treatment for advanced stages of Parkinson's disease and other motor disorders. Although the surgical procedure has gained in accuracy over the years thanks to imaging and microelectrode recordings, the underlying principles of DBS are still debated today. The lack of a clear measurable biomarker for the efficacy of the therapy has rendered efforts to design feedback-enabled stimulators difficult. Our most recent intra-operative recordings have unveiled a new biomarker based on stimulation induced evoked responses that could lead to a new approach to closing the loop and designing an adaptive deep brain stimulator.

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KW - biochemical markers

KW - subthalamus

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Gmel GE, Parker JL, Hamilton TJ. A new biomarker for closed-loop deep brain stimulation in the subthalamic nucleus for patients with Parkinson's disease. In Proceedings IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014: Breakthrough for Distributed Diagnostics and Therapy: 22-24 October 2014, EPFL, Lausanne, Switzerland. IEEE. 2014. p. 500-503 doi: 10.1109/BioCAS.2014.6981772

A new biomarker for closed-loop deep brain stimulation in the subthalamic nucleus for patients with Parkinson's disease

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