A potential role for GPR55 in the regulation of energy homeostasis

Anna C. Simcocks, Lannie O'Keefe, Kayte A. Jenkin, Michael L. Mathai, Deanne H. Hryciw, Andrew J. McAinch

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

G protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor that is expressed in several tissues involved in regulating energy homeostasis, including the hypothalamus, gastrointestinal tract, pancreas, liver, white adipose and skeletal muscle. GPR55 has been shown to have a role in cancer and gastrointestinal inflammation, as well as in obesity and type 2 diabetes mellitus (T2DM). Despite this, the (patho)physiological role of GPR55 in cell dysfunction is still poorly understood, largely because of the limited identification of downstream signalling targets. Nonetheless, research has suggested that GPR55 modulation would be a useful pharmacological target in metabolically active tissues to improve treatment of diseases such as obesity and T2DM. Further research is essential to gain a better understanding of the role that this receptor might have in these and other pathophysiological conditions.
Original languageEnglish
Pages (from-to)1145-1151
Number of pages7
JournalDrug Discovery Today
Volume19
Issue number8
DOIs
Publication statusPublished - 2014

Keywords

  • cannabinoids
  • cell receptors
  • diabetes
  • energy
  • homeostasis
  • obesity

Fingerprint

Dive into the research topics of 'A potential role for GPR55 in the regulation of energy homeostasis'. Together they form a unique fingerprint.

Cite this