A potentially new class of redox-sensitive CEST agents : preliminary Thiol-CEST studies with glutathione and cysteine

Johnny Chen, Nirbhay N. Yadav, T. Stait-Gardner, Abhishek Gupta, William S. Price, Gang Zheng

Research output: Chapter in Book / Conference PaperConference Paper

Abstract

![CDATA[In this study, we show that thiol-water proton exchange can generate MRI contrast by performing proton chemical exchange saturation transfer (1H-CEST) experiments on glutathione (GSH) and cysteine (Cys). The thiol proton exchange was quantified at various pHs, with Cys thiol exhibiting faster and more base-catalyzed exchange than GSH. However, both GSH and Cys thiol exchange were too fast to generate contrast at physiological pH. Potential applications of thiol compounds as redox-sensitive CEST agents are suggested.]]
Original languageEnglish
Title of host publication27th International Society for Magnetic Resonance in Medicine (ISMRM 2019) Annual Meeting and Exhibition, Montreal, QC, Canada, 11-16 May, 2019
PublisherInternational Society for Magnetic Resonance in Medicine
Number of pages5
Publication statusPublished - 2019
EventInternational Society for Magnetic Resonance in Medicine -
Duration: 1 Jan 2019 → …

Conference

ConferenceInternational Society for Magnetic Resonance in Medicine
Period1/01/19 → …

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