Abstract
![CDATA[In this study, we show that thiol-water proton exchange can generate MRI contrast by performing proton chemical exchange saturation transfer (1H-CEST) experiments on glutathione (GSH) and cysteine (Cys). The thiol proton exchange was quantified at various pHs, with Cys thiol exhibiting faster and more base-catalyzed exchange than GSH. However, both GSH and Cys thiol exchange were too fast to generate contrast at physiological pH. Potential applications of thiol compounds as redox-sensitive CEST agents are suggested.]]
Original language | English |
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Title of host publication | 27th International Society for Magnetic Resonance in Medicine (ISMRM 2019) Annual Meeting and Exhibition, Montreal, QC, Canada, 11-16 May, 2019 |
Publisher | International Society for Magnetic Resonance in Medicine |
Number of pages | 5 |
Publication status | Published - 2019 |
Event | International Society for Magnetic Resonance in Medicine - Duration: 1 Jan 2019 → … |
Conference
Conference | International Society for Magnetic Resonance in Medicine |
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Period | 1/01/19 → … |