Abstract
Fluid-phase endocytosis was significantly faster in three lines of human lysosomal storage disease fibroblasts (two I cells and one Sandhoff's) than in three normals. Re-exocytosis of fluid showed similar kinetics in all lines when release was expressed as a percentage of the radioactivity associated with the cells at the commencement of the measurement. This indicates a greater absolute exocytosis of radioactive sucrose from the storage disease cells. The data imply that the interactions of lysosomes with other cellular membranes are perturbed in the storage diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 563-566 |
| Number of pages | 4 |
| Journal | Experimental Cell Research |
| Volume | 151 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 1984 |
| Externally published | Yes |