Acceleration of ethanol metabolism by a patented Bos taurus isolated Alcohol Degradation Protein (ADP) on acute alcohol consumption

Bun Tsoi, Huan Zhang, Chun Pang So, Angel Ka Kei Lam, Christina Chui Wa Poon, Sek Lun Law, Bing Lou Wong, Sai-Wang Seto

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Abstract

Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who inevitably need to consume alcohol. In this study, three different models were used to determine the efficacy of a patented alcohol degradation protein (ADP) extracted from Bos taurus on ethanol metabolism. In an ethanol-challenged HepG2 cell model, ADP significantly protected the cell from ethanol-induced toxicity. Subsequently, results demonstrated that ADP significantly alleviated the effect of ethanol, as reflected by the increased distance and activity time of zebrafish during the testing period. Additionally, in a rat model, ADP promoted ethanol degradation at 1 and 2 h after ethanol consumption. Mechanistic studies found that ADP treatment increased ADH and ALDH activity in the gastrointestinal tract. ADP also exhibited potent antioxidation effects by lowering HO-1 expression in the liver. In conclusion, we believe that ADP is a promising product for relieving hangover symptoms after ethanol consumption, with demonstrated safety and effectiveness at the recommended dosage.

Original languageEnglish
Article number3207
Number of pages10
JournalFoods
Volume13
Issue number19
DOIs
Publication statusPublished - Oct 2024

Bibliographical note

Publisher Copyright:
© 2024 by the authors.

Keywords

  • alcohol degradation
  • hangover
  • liver protection

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