TY - JOUR
T1 - Adenosine role in brain functions : pathophysiological influence on Parkinson's disease and other brain disorders
AU - Soliman, Amira M.
AU - Fathalla, Ahmed M.
AU - Moustafa, Ahmed A.
PY - 2018
Y1 - 2018
N2 - Although adenosine plays a key role in multiple motor, affective, and cognitive processes, it has received less attention in the neuroscience field compared to other neurotransmitters(e.g., dopamine). In this review, we highlight the role of adenosine in behavior as well as its interaction with other neurotransmitters, such as dopamine. We also discuss brain disorders impacted by alterations to adenosine, and how targeting adenosine can ameliorate Parkinson’s disease motor symptoms. We also discuss the role of caffeine (as an adenosine antagonist) on cognition as well as a neuroprotective agent against Parkinson’s disease (PD).
AB - Although adenosine plays a key role in multiple motor, affective, and cognitive processes, it has received less attention in the neuroscience field compared to other neurotransmitters(e.g., dopamine). In this review, we highlight the role of adenosine in behavior as well as its interaction with other neurotransmitters, such as dopamine. We also discuss brain disorders impacted by alterations to adenosine, and how targeting adenosine can ameliorate Parkinson’s disease motor symptoms. We also discuss the role of caffeine (as an adenosine antagonist) on cognition as well as a neuroprotective agent against Parkinson’s disease (PD).
KW - Parkinson's disease
KW - adenosine
UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:45585
U2 - 10.1016/j.pharep.2018.02.003
DO - 10.1016/j.pharep.2018.02.003
M3 - Article
SN - 1734-1140
VL - 70
SP - 661
EP - 667
JO - Pharmacological Reports
JF - Pharmacological Reports
IS - 4
ER -