Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism

Susana Garcia De Arriba; Claudia Loske; Ina Meiners; Gerd Fleischer; Michael Lobisch; Klaus Wessel; Hans Tritschler; Reinhard Schinzel; Gerald Münch

doi:10.1097/01.WCB.0000090622.86921.0E

Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism

Susana Garcia De Arriba, Claudia Loske, Ina Meiners, Gerd Fleischer, Michael Lobisch, Klaus Wessel, Hans Tritschler, Reinhard Schinzel, Gerald Münch

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Advanced glycation endproducts (AGEs) accumulate on long-lived proteins, including β-amyloid plaques in Alzheimer's disease, and are suggested to contribute to neuronal dysfunction and cell death. We have investigated the effects of a model AGE upon glucose metabolism and energy production in a neuroblastoma cell line. AGEs decrease cellular ATP levels and increase glucose consumption and lactate production. All of the AGE-induced metabolic changes can be attenuated by antioxidants such as (R+)-α-lipoic acid and 17β-estradiol. These antioxidants may become useful drugs against (AGE-mediated) effects in neurodegeneration through their positive effects on cellular energy metabolism.

Original language	English
Pages (from-to)	1307-1313
Number of pages	7
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	23
Issue number	11
DOIs	https://doi.org/10.1097/01.WCB.0000090622.86921.0E
Publication status	Published - Nov 2003
Externally published	Yes

Keywords

Advanced glycation endproducts
Antioxidants
Lactate
Lipoic acid
Oxidative stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/01.WCB.0000090622.86921.0E

Cite this

De Arriba, S. G., Loske, C., Meiners, I., Fleischer, G., Lobisch, M., Wessel, K., Tritschler, H., Schinzel, R., & Münch, G. (2003). Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism. Journal of Cerebral Blood Flow and Metabolism, 23(11), 1307-1313. https://doi.org/10.1097/01.WCB.0000090622.86921.0E

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title = "Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism",

abstract = "Advanced glycation endproducts (AGEs) accumulate on long-lived proteins, including β-amyloid plaques in Alzheimer's disease, and are suggested to contribute to neuronal dysfunction and cell death. We have investigated the effects of a model AGE upon glucose metabolism and energy production in a neuroblastoma cell line. AGEs decrease cellular ATP levels and increase glucose consumption and lactate production. All of the AGE-induced metabolic changes can be attenuated by antioxidants such as (R+)-α-lipoic acid and 17β-estradiol. These antioxidants may become useful drugs against (AGE-mediated) effects in neurodegeneration through their positive effects on cellular energy metabolism.",

keywords = "Advanced glycation endproducts, Antioxidants, Lactate, Lipoic acid, Oxidative stress",

author = "{De Arriba}, {Susana Garcia} and Claudia Loske and Ina Meiners and Gerd Fleischer and Michael Lobisch and Klaus Wessel and Hans Tritschler and Reinhard Schinzel and Gerald M{\"u}nch",

year = "2003",

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doi = "10.1097/01.WCB.0000090622.86921.0E",

language = "English",

volume = "23",

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journal = "Journal of Cerebral Blood Flow and Metabolism",

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De Arriba, SG, Loske, C, Meiners, I, Fleischer, G, Lobisch, M, Wessel, K, Tritschler, H, Schinzel, R & Münch, G 2003, 'Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism', Journal of Cerebral Blood Flow and Metabolism, vol. 23, no. 11, pp. 1307-1313. https://doi.org/10.1097/01.WCB.0000090622.86921.0E

Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism. / De Arriba, Susana Garcia; Loske, Claudia; Meiners, Ina et al.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 23, No. 11, 11.2003, p. 1307-1313.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism

AU - De Arriba, Susana Garcia

AU - Loske, Claudia

AU - Meiners, Ina

AU - Fleischer, Gerd

AU - Lobisch, Michael

AU - Wessel, Klaus

AU - Tritschler, Hans

AU - Schinzel, Reinhard

AU - Münch, Gerald

PY - 2003/11

Y1 - 2003/11

N2 - Advanced glycation endproducts (AGEs) accumulate on long-lived proteins, including β-amyloid plaques in Alzheimer's disease, and are suggested to contribute to neuronal dysfunction and cell death. We have investigated the effects of a model AGE upon glucose metabolism and energy production in a neuroblastoma cell line. AGEs decrease cellular ATP levels and increase glucose consumption and lactate production. All of the AGE-induced metabolic changes can be attenuated by antioxidants such as (R+)-α-lipoic acid and 17β-estradiol. These antioxidants may become useful drugs against (AGE-mediated) effects in neurodegeneration through their positive effects on cellular energy metabolism.

AB - Advanced glycation endproducts (AGEs) accumulate on long-lived proteins, including β-amyloid plaques in Alzheimer's disease, and are suggested to contribute to neuronal dysfunction and cell death. We have investigated the effects of a model AGE upon glucose metabolism and energy production in a neuroblastoma cell line. AGEs decrease cellular ATP levels and increase glucose consumption and lactate production. All of the AGE-induced metabolic changes can be attenuated by antioxidants such as (R+)-α-lipoic acid and 17β-estradiol. These antioxidants may become useful drugs against (AGE-mediated) effects in neurodegeneration through their positive effects on cellular energy metabolism.

KW - Advanced glycation endproducts

KW - Antioxidants

KW - Lactate

KW - Lipoic acid

KW - Oxidative stress

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U2 - 10.1097/01.WCB.0000090622.86921.0E

DO - 10.1097/01.WCB.0000090622.86921.0E

M3 - Article

C2 - 14600438

AN - SCOPUS:0242658561

SN - 0271-678X

VL - 23

SP - 1307

EP - 1313

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

IS - 11

ER -

Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism

Abstract

Keywords

UN SDGs

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