TY - JOUR
T1 - Advantages of breast cancer visualization and characterization using synchrotron radiation phase-contrast tomography
AU - Pacilè, S.
AU - Baran, P.
AU - Dullin, C.
AU - Dimmock, M.
AU - Lockie, D.
AU - Missbach-Guntner, J.
AU - Quiney, H.
AU - McCormack, M.
AU - Mayo, S.
AU - Thompson, D.
AU - Nesterets, Y.
AU - Hall, C.
AU - Pavlov, K.
AU - Prodanovic, Z.
AU - Tonutti, M.
AU - Accardo, A.
AU - Fox, J.
AU - Tavakoli Taba, Seyedamir
AU - Lewis, Sarah
AU - Brennan, P.
AU - Hausermann, D.
AU - Tromba, G.
AU - Gureyev, T.
PY - 2018
Y1 - 2018
N2 - The aim of this study was to highlight the advantages that propagation-based phase-contrast computed tomography (PB-CT) with synchrotron radiation can provide in breast cancer diagnostics. For the first time, a fresh and intact mastectomy sample from a 60 year old patient was scanned on the IMBL beamline at the Australian Synchrotron in PB-CT mode and reconstructed. The clinical picture was described and characterized by an experienced breast radiologist, who underlined the advantages of providing diagnosis on a PB-CT volume rather than conventional two-dimensional modalities. Subsequently, the image quality was assessed by 11 breast radiologists and medical imaging experts using a radiological scoring system. The results indicate that, with the radiation dose delivered to the sample being equal, the accuracy of a diagnosis made on PB-CT images is significantly higher than one using conventional techniques.
AB - The aim of this study was to highlight the advantages that propagation-based phase-contrast computed tomography (PB-CT) with synchrotron radiation can provide in breast cancer diagnostics. For the first time, a fresh and intact mastectomy sample from a 60 year old patient was scanned on the IMBL beamline at the Australian Synchrotron in PB-CT mode and reconstructed. The clinical picture was described and characterized by an experienced breast radiologist, who underlined the advantages of providing diagnosis on a PB-CT volume rather than conventional two-dimensional modalities. Subsequently, the image quality was assessed by 11 breast radiologists and medical imaging experts using a radiological scoring system. The results indicate that, with the radiation dose delivered to the sample being equal, the accuracy of a diagnosis made on PB-CT images is significantly higher than one using conventional techniques.
UR - https://hdl.handle.net/1959.7/uws:74526
U2 - 10.1107/S1600577518010172
DO - 10.1107/S1600577518010172
M3 - Article
SN - 0909-0495
VL - 25
SP - 1460
EP - 1466
JO - Journal of Synchrotron Radiation
JF - Journal of Synchrotron Radiation
IS - 5
ER -
