Amines Induce Increased Thromboplastin Activity in Human Monocytes

Roger T. DEAN; Hans PRYDZ

doi:10.1111/j.1432-1033.1983.tb07313.x

Amines Induce Increased Thromboplastin Activity in Human Monocytes

Roger T. DEAN
, Hans PRYDZ

Brunel University London
University of Oslo

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A variety of amines induced a dose‐dependent and time‐dependent increase in thromboplastin activity of cultured human monocytes. The increase required protein synthesis, and reached a peak after about 18 h. Some inhibitory effects were noted at low concentrations of NH₄Cl. It is suggested that the amines act by raising the pH of acidic intracellular compartments.

Original language	English
Pages (from-to)	655-658
Number of pages	4
Journal	European Journal of Biochemistry
Volume	131
Issue number	3
DOIs	https://doi.org/10.1111/j.1432-1033.1983.tb07313.x
Publication status	Published - Apr 1983
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1111/j.1432-1033.1983.tb07313.x

Cite this

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title = "Amines Induce Increased Thromboplastin Activity in Human Monocytes",

abstract = "A variety of amines induced a dose‐dependent and time‐dependent increase in thromboplastin activity of cultured human monocytes. The increase required protein synthesis, and reached a peak after about 18 h. Some inhibitory effects were noted at low concentrations of NH4Cl. It is suggested that the amines act by raising the pH of acidic intracellular compartments.",

author = "DEAN, \{Roger T.\} and Hans PRYDZ",

year = "1983",

month = apr,

doi = "10.1111/j.1432-1033.1983.tb07313.x",

language = "English",

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T1 - Amines Induce Increased Thromboplastin Activity in Human Monocytes

AU - DEAN, Roger T.

AU - PRYDZ, Hans

PY - 1983/4

Y1 - 1983/4

N2 - A variety of amines induced a dose‐dependent and time‐dependent increase in thromboplastin activity of cultured human monocytes. The increase required protein synthesis, and reached a peak after about 18 h. Some inhibitory effects were noted at low concentrations of NH4Cl. It is suggested that the amines act by raising the pH of acidic intracellular compartments.

AB - A variety of amines induced a dose‐dependent and time‐dependent increase in thromboplastin activity of cultured human monocytes. The increase required protein synthesis, and reached a peak after about 18 h. Some inhibitory effects were noted at low concentrations of NH4Cl. It is suggested that the amines act by raising the pH of acidic intracellular compartments.

UR - https://www.scopus.com/pages/publications/0020531402

U2 - 10.1111/j.1432-1033.1983.tb07313.x

DO - 10.1111/j.1432-1033.1983.tb07313.x

M3 - Article

C2 - 6840074

AN - SCOPUS:0020531402

SN - 0014-2956

VL - 131

SP - 655

EP - 658

JO - European Journal of Biochemistry

JF - European Journal of Biochemistry

IS - 3

ER -

Amines Induce Increased Thromboplastin Activity in Human Monocytes

Abstract

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