Amines Induce Increased Thromboplastin Activity in Human Monocytes

Roger T. DEAN; Hans PRYDZ

doi:10.1111/j.1432-1033.1983.tb07313.x

Amines Induce Increased Thromboplastin Activity in Human Monocytes

Roger T. DEAN, Hans PRYDZ

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A variety of amines induced a dose‐dependent and time‐dependent increase in thromboplastin activity of cultured human monocytes. The increase required protein synthesis, and reached a peak after about 18 h. Some inhibitory effects were noted at low concentrations of NH₄Cl. It is suggested that the amines act by raising the pH of acidic intracellular compartments.

Original language	English
Pages (from-to)	655-658
Number of pages	4
Journal	European Journal of Biochemistry
Volume	131
Issue number	3
DOIs	https://doi.org/10.1111/j.1432-1033.1983.tb07313.x
Publication status	Published - Apr 1983
Externally published	Yes

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10.1111/j.1432-1033.1983.tb07313.x

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title = "Amines Induce Increased Thromboplastin Activity in Human Monocytes",

abstract = "A variety of amines induced a dose‐dependent and time‐dependent increase in thromboplastin activity of cultured human monocytes. The increase required protein synthesis, and reached a peak after about 18 h. Some inhibitory effects were noted at low concentrations of NH4Cl. It is suggested that the amines act by raising the pH of acidic intracellular compartments.",

author = "DEAN, {Roger T.} and Hans PRYDZ",

year = "1983",

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AU - DEAN, Roger T.

AU - PRYDZ, Hans

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N2 - A variety of amines induced a dose‐dependent and time‐dependent increase in thromboplastin activity of cultured human monocytes. The increase required protein synthesis, and reached a peak after about 18 h. Some inhibitory effects were noted at low concentrations of NH4Cl. It is suggested that the amines act by raising the pH of acidic intracellular compartments.

AB - A variety of amines induced a dose‐dependent and time‐dependent increase in thromboplastin activity of cultured human monocytes. The increase required protein synthesis, and reached a peak after about 18 h. Some inhibitory effects were noted at low concentrations of NH4Cl. It is suggested that the amines act by raising the pH of acidic intracellular compartments.

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U2 - 10.1111/j.1432-1033.1983.tb07313.x

DO - 10.1111/j.1432-1033.1983.tb07313.x

M3 - Article

C2 - 6840074

AN - SCOPUS:0020531402

SN - 0014-2956

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SP - 655

EP - 658

JO - European Journal of Biochemistry

JF - European Journal of Biochemistry

IS - 3

ER -

Amines Induce Increased Thromboplastin Activity in Human Monocytes

Abstract

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