An adaptive measure of visuospatial impairment in dementia with Lewy bodies

Joseph R. Phillips; Elie Matar; Kaylena A. Ehgoetz Martens; Ahmed A. Moustafa; Glenda M. Halliday; Simon J. G. Lewis

doi:10.1002/mdc3.13488

An adaptive measure of visuospatial impairment in dementia with Lewy bodies

Joseph R. Phillips, Elie Matar, Kaylena A. Ehgoetz Martens, Ahmed A. Moustafa, Glenda M. Halliday, Simon J. G. Lewis

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background: Dementia with Lewy bodies (DLB) is a common cause of dementia with poor prognosis and high hospitalization rates. DLB is frequently misdiagnosed, with clinical features that overlap significantly with other diseases including Parkinson's disease (PD). Clinical instruments that discriminate and track the progression of cognitive impairment in DLB are needed. Objectives: The current study was designed to assess the utility of a mental rotation (MR) task for assessing visuospatial impairments in early DLB. Methods: Accuracy of 22 DLB patients, 22 PD patients and 22 age-matched healthy controls in the MR task were compared at comparing shapes with 0°, 45° and 90° rotations. Results: Healthy controls and PD patients performed at similar levels while the DLB group were significantly impaired. Further, impairment in the visuospatial and executive function measures correlated with MR poor outcomes. Conclusion: These findings support the MR task as an objective measure of visuospatial impairment with the ability to adjust difficulty to suit impairments in a DLB population. This would be a useful tool within clinical trials.

Original language	English
Pages (from-to)	619-627
Number of pages	9
Journal	Movement Disorders Clinical Practice
Volume	9
Issue number	5
DOIs	https://doi.org/10.1002/mdc3.13488
Publication status	Published - Jul 2022

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© 2022 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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10.1002/mdc3.13488

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title = "An adaptive measure of visuospatial impairment in dementia with Lewy bodies",

abstract = "Background: Dementia with Lewy bodies (DLB) is a common cause of dementia with poor prognosis and high hospitalization rates. DLB is frequently misdiagnosed, with clinical features that overlap significantly with other diseases including Parkinson's disease (PD). Clinical instruments that discriminate and track the progression of cognitive impairment in DLB are needed. Objectives: The current study was designed to assess the utility of a mental rotation (MR) task for assessing visuospatial impairments in early DLB. Methods: Accuracy of 22 DLB patients, 22 PD patients and 22 age-matched healthy controls in the MR task were compared at comparing shapes with 0°, 45° and 90° rotations. Results: Healthy controls and PD patients performed at similar levels while the DLB group were significantly impaired. Further, impairment in the visuospatial and executive function measures correlated with MR poor outcomes. Conclusion: These findings support the MR task as an objective measure of visuospatial impairment with the ability to adjust difficulty to suit impairments in a DLB population. This would be a useful tool within clinical trials.",

author = "Phillips, {Joseph R.} and Elie Matar and {Ehgoetz Martens}, {Kaylena A.} and Moustafa, {Ahmed A.} and Halliday, {Glenda M.} and Lewis, {Simon J. G.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.",

year = "2022",

month = jul,

doi = "10.1002/mdc3.13488",

language = "English",

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T1 - An adaptive measure of visuospatial impairment in dementia with Lewy bodies

AU - Phillips, Joseph R.

AU - Matar, Elie

AU - Ehgoetz Martens, Kaylena A.

AU - Moustafa, Ahmed A.

AU - Halliday, Glenda M.

AU - Lewis, Simon J. G.

PY - 2022/7

Y1 - 2022/7

N2 - Background: Dementia with Lewy bodies (DLB) is a common cause of dementia with poor prognosis and high hospitalization rates. DLB is frequently misdiagnosed, with clinical features that overlap significantly with other diseases including Parkinson's disease (PD). Clinical instruments that discriminate and track the progression of cognitive impairment in DLB are needed. Objectives: The current study was designed to assess the utility of a mental rotation (MR) task for assessing visuospatial impairments in early DLB. Methods: Accuracy of 22 DLB patients, 22 PD patients and 22 age-matched healthy controls in the MR task were compared at comparing shapes with 0°, 45° and 90° rotations. Results: Healthy controls and PD patients performed at similar levels while the DLB group were significantly impaired. Further, impairment in the visuospatial and executive function measures correlated with MR poor outcomes. Conclusion: These findings support the MR task as an objective measure of visuospatial impairment with the ability to adjust difficulty to suit impairments in a DLB population. This would be a useful tool within clinical trials.

AB - Background: Dementia with Lewy bodies (DLB) is a common cause of dementia with poor prognosis and high hospitalization rates. DLB is frequently misdiagnosed, with clinical features that overlap significantly with other diseases including Parkinson's disease (PD). Clinical instruments that discriminate and track the progression of cognitive impairment in DLB are needed. Objectives: The current study was designed to assess the utility of a mental rotation (MR) task for assessing visuospatial impairments in early DLB. Methods: Accuracy of 22 DLB patients, 22 PD patients and 22 age-matched healthy controls in the MR task were compared at comparing shapes with 0°, 45° and 90° rotations. Results: Healthy controls and PD patients performed at similar levels while the DLB group were significantly impaired. Further, impairment in the visuospatial and executive function measures correlated with MR poor outcomes. Conclusion: These findings support the MR task as an objective measure of visuospatial impairment with the ability to adjust difficulty to suit impairments in a DLB population. This would be a useful tool within clinical trials.

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JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

IS - 5

ER -

An adaptive measure of visuospatial impairment in dementia with Lewy bodies

Abstract

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