TY - JOUR
T1 - An in vitro study of the photodynamic effect of rose bengal on Trichophyton rubrum
AU - Cronin, Leah
AU - Moffitt, Michelle
AU - Mawad, Damia
AU - Morton, Oliver C.
AU - Lauto, Antonio
AU - Stack, Colin
PY - 2014
Y1 - 2014
N2 - Onychomycosis, a fungal infection of the finger or toenails, is predominantly caused by Trichophyton rubrum. Treatment is difficult due to high recurrence rates and problems with treatment compliance. For these reasons, alternative therapies are needed. Here we describe the photoactivation of Rose Bengal (RB) using a green laser (ƛ = 532 nm) at fluences of 68, 133 and 228 J/cm2, and assess its fungicidal activity on T. rubrum spore suspensions. A 140 µM RB solution was able to induce a fungicidal effect on T. rubrum when photosensitized with the fluence of 228 J/cm2. RB photosensitization using a green laser provides a potential novel treatment for T. rubrum infections.
AB - Onychomycosis, a fungal infection of the finger or toenails, is predominantly caused by Trichophyton rubrum. Treatment is difficult due to high recurrence rates and problems with treatment compliance. For these reasons, alternative therapies are needed. Here we describe the photoactivation of Rose Bengal (RB) using a green laser (ƛ = 532 nm) at fluences of 68, 133 and 228 J/cm2, and assess its fungicidal activity on T. rubrum spore suspensions. A 140 µM RB solution was able to induce a fungicidal effect on T. rubrum when photosensitized with the fluence of 228 J/cm2. RB photosensitization using a green laser provides a potential novel treatment for T. rubrum infections.
UR - http://handle.uws.edu.au:8081/1959.7/543570
U2 - 10.1002/jbio.201200168
DO - 10.1002/jbio.201200168
M3 - Article
SN - 1864-063X
VL - 7
SP - 410
EP - 417
JO - Journal of Biophotonics
JF - Journal of Biophotonics
IS - 6
ER -