TY - JOUR
T1 - Analysis of mitochondrial DNA heteroplasmic mutations A1555G, C3256T, T3336C, C5178A, G12315A, G13513A, G14459A, G14846A and G15059A in CHD patients with the history of myocardial infarction
AU - Mitrofanov, Konstantin Y.
AU - Zhelankin, Andrey V.
AU - Shiganova, G. M.
AU - Sazonova, Margarita A.
AU - Bobryshev, Yuri V.
AU - Postnov, Anton Y.
AU - Sobenin, Igor A.
AU - Orekhov, Alexander N.
PY - 2016
Y1 - 2016
N2 - The present study was undertaken in order to advance our earlier studies directed to define genetic risk of atherosclerotic vascular lesion development on a base on the analysis of sets of mutational load relevant to the mitochondrial genome mutations. A comparative evaluation of the two study participants’ populations (that included coronary heart disease (CHD) patients who underwent myocardial infarction and apparently healthy donors with no clinical manifestations of coronary heart disease) on heteroplasmy levels of nine mutations of the mitochondrial genome (A1555G, C3256T, T3336C, С5178А, G12315A, G13513A, G14459A, G14846А and G15059A) that were shown previously to be associated with risk factors for atherosclerosis was performed. Close associations with the risk of cardiovascular disease were confirmed for mutation C3256T (gene MT-TL1), G12315A (gene MT-TL2), G13513A (gene MT-ND5) and G15059A (gene MT-CYB) by RT-PCR.
AB - The present study was undertaken in order to advance our earlier studies directed to define genetic risk of atherosclerotic vascular lesion development on a base on the analysis of sets of mutational load relevant to the mitochondrial genome mutations. A comparative evaluation of the two study participants’ populations (that included coronary heart disease (CHD) patients who underwent myocardial infarction and apparently healthy donors with no clinical manifestations of coronary heart disease) on heteroplasmy levels of nine mutations of the mitochondrial genome (A1555G, C3256T, T3336C, С5178А, G12315A, G13513A, G14459A, G14846А and G15059A) that were shown previously to be associated with risk factors for atherosclerosis was performed. Close associations with the risk of cardiovascular disease were confirmed for mutation C3256T (gene MT-TL1), G12315A (gene MT-TL2), G13513A (gene MT-ND5) and G15059A (gene MT-CYB) by RT-PCR.
KW - coronary heart disease
KW - heteroplasmy
KW - mitochondrial DNA
KW - myocardial infarction
UR - http://handle.uws.edu.au:8081/1959.7/uws:32970
U2 - 10.1016/j.yexmp.2015.12.003
DO - 10.1016/j.yexmp.2015.12.003
M3 - Article
SN - 0014-4800
VL - 100
SP - 87
EP - 91
JO - Experimental and Molecular Pathology
JF - Experimental and Molecular Pathology
IS - 1
ER -
