Analysis of mitochondrial DNA heteroplasmic mutations A1555G, C3256T, T3336C, C5178A, G12315A, G13513A, G14459A, G14846A and G15059A in CHD patients with the history of myocardial infarction

Konstantin Y. Mitrofanov; Andrey V. Zhelankin; G. M. Shiganova; Margarita A. Sazonova; Yuri V. Bobryshev; Anton Y. Postnov; Igor A. Sobenin; Alexander N. Orekhov

doi:10.1016/j.yexmp.2015.12.003

Analysis of mitochondrial DNA heteroplasmic mutations A1555G, C3256T, T3336C, C5178A, G12315A, G13513A, G14459A, G14846A and G15059A in CHD patients with the history of myocardial infarction

Konstantin Y. Mitrofanov
, Andrey V. Zhelankin
, G. M. Shiganova
, Margarita A. Sazonova
, Yuri V. Bobryshev
, Anton Y. Postnov
, Igor A. Sobenin
, Alexander N. Orekhov

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The present study was undertaken in order to advance our earlier studies directed to define genetic risk of atherosclerotic vascular lesion development on a base on the analysis of sets of mutational load relevant to the mitochondrial genome mutations. A comparative evaluation of the two study participants' populations (that included coronary heart disease (CHD) patients who underwent myocardial infarction and apparently healthy donors with no clinical manifestations of coronary heart disease) on heteroplasmy levels of nine mutations of the mitochondrial genome (A1555G, C3256T, T3336C, Ð¡5178Ð, G12315A, G13513A, G14459A, G14846Ð and G15059A) that were shown previously to be associated with risk factors for atherosclerosis was performed. Close associations with the risk of cardiovascular disease were confirmed for mutation C3256T (gene MT-TL1), G12315A (gene MT-TL2), G13513A (gene MT-ND5) and G15059A (gene MT-CYB) by RT-PCR.

Original language	English
Pages (from-to)	87-91
Number of pages	16
Journal	Experimental and Molecular Pathology
Volume	100
Issue number	1
DOIs	https://doi.org/10.1016/j.yexmp.2015.12.003
Publication status	Published - 2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

coronary heart disease
heteroplasmy
mitochondrial DNA
myocardial infarction

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10.1016/j.yexmp.2015.12.003

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Mitrofanov, K. Y., Zhelankin, A. V., Shiganova, G. M., Sazonova, M. A., Bobryshev, Y. V., Postnov, A. Y., Sobenin, I. A., & Orekhov, A. N. (2016). Analysis of mitochondrial DNA heteroplasmic mutations A1555G, C3256T, T3336C, C5178A, G12315A, G13513A, G14459A, G14846A and G15059A in CHD patients with the history of myocardial infarction. Experimental and Molecular Pathology, 100(1), 87-91. https://doi.org/10.1016/j.yexmp.2015.12.003

@article{0c3eac34e259436aa3d4225c093eda6a,

title = "Analysis of mitochondrial DNA heteroplasmic mutations A1555G, C3256T, T3336C, C5178A, G12315A, G13513A, G14459A, G14846A and G15059A in CHD patients with the history of myocardial infarction",

abstract = "The present study was undertaken in order to advance our earlier studies directed to define genetic risk of atherosclerotic vascular lesion development on a base on the analysis of sets of mutational load relevant to the mitochondrial genome mutations. A comparative evaluation of the two study participants' populations (that included coronary heart disease (CHD) patients who underwent myocardial infarction and apparently healthy donors with no clinical manifestations of coronary heart disease) on heteroplasmy levels of nine mutations of the mitochondrial genome (A1555G, C3256T, T3336C, {\DH}¡5178{\DH}, G12315A, G13513A, G14459A, G14846{\DH} and G15059A) that were shown previously to be associated with risk factors for atherosclerosis was performed. Close associations with the risk of cardiovascular disease were confirmed for mutation C3256T (gene MT-TL1), G12315A (gene MT-TL2), G13513A (gene MT-ND5) and G15059A (gene MT-CYB) by RT-PCR.",

keywords = "coronary heart disease, heteroplasmy, mitochondrial DNA, myocardial infarction",

author = "Mitrofanov, \{Konstantin Y.\} and Zhelankin, \{Andrey V.\} and Shiganova, \{G. M.\} and Sazonova, \{Margarita A.\} and Bobryshev, \{Yuri V.\} and Postnov, \{Anton Y.\} and Sobenin, \{Igor A.\} and Orekhov, \{Alexander N.\}",

year = "2016",

doi = "10.1016/j.yexmp.2015.12.003",

language = "English",

volume = "100",

pages = "87--91",

journal = "Experimental and Molecular Pathology",

issn = "0014-4800",

publisher = "Academic Press",

number = "1",

}

Mitrofanov, KY, Zhelankin, AV, Shiganova, GM, Sazonova, MA, Bobryshev, YV, Postnov, AY, Sobenin, IA & Orekhov, AN 2016, 'Analysis of mitochondrial DNA heteroplasmic mutations A1555G, C3256T, T3336C, C5178A, G12315A, G13513A, G14459A, G14846A and G15059A in CHD patients with the history of myocardial infarction', Experimental and Molecular Pathology, vol. 100, no. 1, pp. 87-91. https://doi.org/10.1016/j.yexmp.2015.12.003

Analysis of mitochondrial DNA heteroplasmic mutations A1555G, C3256T, T3336C, C5178A, G12315A, G13513A, G14459A, G14846A and G15059A in CHD patients with the history of myocardial infarction. / Mitrofanov, Konstantin Y.; Zhelankin, Andrey V.; Shiganova, G. M. et al.
In: Experimental and Molecular Pathology, Vol. 100, No. 1, 2016, p. 87-91.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Analysis of mitochondrial DNA heteroplasmic mutations A1555G, C3256T, T3336C, C5178A, G12315A, G13513A, G14459A, G14846A and G15059A in CHD patients with the history of myocardial infarction

AU - Mitrofanov, Konstantin Y.

AU - Zhelankin, Andrey V.

AU - Shiganova, G. M.

AU - Sazonova, Margarita A.

AU - Bobryshev, Yuri V.

AU - Postnov, Anton Y.

AU - Sobenin, Igor A.

AU - Orekhov, Alexander N.

PY - 2016

Y1 - 2016

N2 - The present study was undertaken in order to advance our earlier studies directed to define genetic risk of atherosclerotic vascular lesion development on a base on the analysis of sets of mutational load relevant to the mitochondrial genome mutations. A comparative evaluation of the two study participants' populations (that included coronary heart disease (CHD) patients who underwent myocardial infarction and apparently healthy donors with no clinical manifestations of coronary heart disease) on heteroplasmy levels of nine mutations of the mitochondrial genome (A1555G, C3256T, T3336C, Ð¡5178Ð, G12315A, G13513A, G14459A, G14846Ð and G15059A) that were shown previously to be associated with risk factors for atherosclerosis was performed. Close associations with the risk of cardiovascular disease were confirmed for mutation C3256T (gene MT-TL1), G12315A (gene MT-TL2), G13513A (gene MT-ND5) and G15059A (gene MT-CYB) by RT-PCR.

AB - The present study was undertaken in order to advance our earlier studies directed to define genetic risk of atherosclerotic vascular lesion development on a base on the analysis of sets of mutational load relevant to the mitochondrial genome mutations. A comparative evaluation of the two study participants' populations (that included coronary heart disease (CHD) patients who underwent myocardial infarction and apparently healthy donors with no clinical manifestations of coronary heart disease) on heteroplasmy levels of nine mutations of the mitochondrial genome (A1555G, C3256T, T3336C, Ð¡5178Ð, G12315A, G13513A, G14459A, G14846Ð and G15059A) that were shown previously to be associated with risk factors for atherosclerosis was performed. Close associations with the risk of cardiovascular disease were confirmed for mutation C3256T (gene MT-TL1), G12315A (gene MT-TL2), G13513A (gene MT-ND5) and G15059A (gene MT-CYB) by RT-PCR.

KW - coronary heart disease

KW - heteroplasmy

KW - mitochondrial DNA

KW - myocardial infarction

UR - http://handle.uws.edu.au:8081/1959.7/uws:32970

U2 - 10.1016/j.yexmp.2015.12.003

DO - 10.1016/j.yexmp.2015.12.003

M3 - Article

SN - 0014-4800

VL - 100

SP - 87

EP - 91

JO - Experimental and Molecular Pathology

JF - Experimental and Molecular Pathology

IS - 1

ER -

Analysis of mitochondrial DNA heteroplasmic mutations A1555G, C3256T, T3336C, C5178A, G12315A, G13513A, G14459A, G14846A and G15059A in CHD patients with the history of myocardial infarction

Abstract

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Keywords

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