Anti-inflammatory and neuroprotective effect of apigenin : studies in the GFAP-IL6 mouse model of chronic neuroinflammation

H. Liang; S. Sonego; E. Gyengesi; A. Rangel; G. Niedermayer; T. Karl; G. Munch

doi:10.1016/j.freeradbiomed.2017.04.064

Anti-inflammatory and neuroprotective effect of apigenin : studies in the GFAP-IL6 mouse model of chronic neuroinflammation

H. Liang, S. Sonego, E. Gyengesi, A. Rangel, G. Niedermayer, T. Karl, G. Munch

Research output: Chapter in Book / Conference Paper › Conference Paper

Abstract

Chronic neuroinflammation (activation of microglia and astrocytes) is a prominent pathological process in many neurodegenerative diseases including Alzheimer's disease (AD). Consequently, it has been suggested that drugs targeting neuroinflammatory processes such as cytokine-suppressive anti-inflammatory drugs (CSAIDs) such as apigenin (major bioactive compound in parsley) might yield clinically useful disease- modifying effect for these neurodegenerative disorders. The present study aimed to investigate the therapeutic effect of apigenin on neuroinflammation in the glial fibrillary acidic protein-interleukin 6 (GFAPIL6) expressing mouse using both immunohistochemical and behavioral tests.

Original language	English
Title of host publication	Free Radical Biology and Medicine. Volume 108, Supplement 1: Abstracts of the OCC World Congress and Annual SFRR-E Conference 2017: Metabolic Stress and Redox Regulation, Berlin, Germany, 21-23 June 2017
Publisher	Elsevier
Pages	S10-S10
Number of pages	1
DOIs	https://doi.org/10.1016/j.freeradbiomed.2017.04.064
Publication status	Published - 2017
Event	Oxygen Club of California. World Congress - Duration: 1 Jan 2017 → …

Conference

Conference	Oxygen Club of California. World Congress
Period	1/01/17 → …

Keywords

apigenin
anti-inflammatory agents
Alzheimer's disease
cytokines
parsley

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10.1016/j.freeradbiomed.2017.04.064

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Liang, H., Sonego, S., Gyengesi, E., Rangel, A., Niedermayer, G., Karl, T., & Munch, G. (2017). Anti-inflammatory and neuroprotective effect of apigenin : studies in the GFAP-IL6 mouse model of chronic neuroinflammation. In Free Radical Biology and Medicine. Volume 108, Supplement 1: Abstracts of the OCC World Congress and Annual SFRR-E Conference 2017: Metabolic Stress and Redox Regulation, Berlin, Germany, 21-23 June 2017 (pp. S10-S10). Elsevier. https://doi.org/10.1016/j.freeradbiomed.2017.04.064

Liang, H. ; Sonego, S. ; Gyengesi, E. et al. / Anti-inflammatory and neuroprotective effect of apigenin : studies in the GFAP-IL6 mouse model of chronic neuroinflammation. Free Radical Biology and Medicine. Volume 108, Supplement 1: Abstracts of the OCC World Congress and Annual SFRR-E Conference 2017: Metabolic Stress and Redox Regulation, Berlin, Germany, 21-23 June 2017. Elsevier, 2017. pp. S10-S10

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title = "Anti-inflammatory and neuroprotective effect of apigenin : studies in the GFAP-IL6 mouse model of chronic neuroinflammation",

abstract = "Chronic neuroinflammation (activation of microglia and astrocytes) is a prominent pathological process in many neurodegenerative diseases including Alzheimer's disease (AD). Consequently, it has been suggested that drugs targeting neuroinflammatory processes such as cytokine-suppressive anti-inflammatory drugs (CSAIDs) such as apigenin (major bioactive compound in parsley) might yield clinically useful disease- modifying effect for these neurodegenerative disorders. The present study aimed to investigate the therapeutic effect of apigenin on neuroinflammation in the glial fibrillary acidic protein-interleukin 6 (GFAPIL6) expressing mouse using both immunohistochemical and behavioral tests.",

keywords = "apigenin, anti-inflammatory agents, Alzheimer's disease, cytokines, parsley",

author = "H. Liang and S. Sonego and E. Gyengesi and A. Rangel and G. Niedermayer and T. Karl and G. Munch",

year = "2017",

doi = "10.1016/j.freeradbiomed.2017.04.064",

language = "English",

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booktitle = "Free Radical Biology and Medicine. Volume 108, Supplement 1: Abstracts of the OCC World Congress and Annual SFRR-E Conference 2017: Metabolic Stress and Redox Regulation, Berlin, Germany, 21-23 June 2017",

publisher = "Elsevier",

note = "Oxygen Club of California. World Congress ; Conference date: 01-01-2017",

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Liang, H, Sonego, S, Gyengesi, E, Rangel, A, Niedermayer, G , Karl, T & Munch, G 2017, Anti-inflammatory and neuroprotective effect of apigenin : studies in the GFAP-IL6 mouse model of chronic neuroinflammation. in Free Radical Biology and Medicine. Volume 108, Supplement 1: Abstracts of the OCC World Congress and Annual SFRR-E Conference 2017: Metabolic Stress and Redox Regulation, Berlin, Germany, 21-23 June 2017. Elsevier, pp. S10-S10, Oxygen Club of California. World Congress, 1/01/17. https://doi.org/10.1016/j.freeradbiomed.2017.04.064

Anti-inflammatory and neuroprotective effect of apigenin : studies in the GFAP-IL6 mouse model of chronic neuroinflammation. / Liang, H.; Sonego, S.; Gyengesi, E. et al.
Free Radical Biology and Medicine. Volume 108, Supplement 1: Abstracts of the OCC World Congress and Annual SFRR-E Conference 2017: Metabolic Stress and Redox Regulation, Berlin, Germany, 21-23 June 2017. Elsevier, 2017. p. S10-S10.

Research output: Chapter in Book / Conference Paper › Conference Paper

TY - GEN

T1 - Anti-inflammatory and neuroprotective effect of apigenin : studies in the GFAP-IL6 mouse model of chronic neuroinflammation

AU - Liang, H.

AU - Sonego, S.

AU - Gyengesi, E.

AU - Rangel, A.

AU - Niedermayer, G.

AU - Karl, T.

AU - Munch, G.

PY - 2017

Y1 - 2017

N2 - Chronic neuroinflammation (activation of microglia and astrocytes) is a prominent pathological process in many neurodegenerative diseases including Alzheimer's disease (AD). Consequently, it has been suggested that drugs targeting neuroinflammatory processes such as cytokine-suppressive anti-inflammatory drugs (CSAIDs) such as apigenin (major bioactive compound in parsley) might yield clinically useful disease- modifying effect for these neurodegenerative disorders. The present study aimed to investigate the therapeutic effect of apigenin on neuroinflammation in the glial fibrillary acidic protein-interleukin 6 (GFAPIL6) expressing mouse using both immunohistochemical and behavioral tests.

AB - Chronic neuroinflammation (activation of microglia and astrocytes) is a prominent pathological process in many neurodegenerative diseases including Alzheimer's disease (AD). Consequently, it has been suggested that drugs targeting neuroinflammatory processes such as cytokine-suppressive anti-inflammatory drugs (CSAIDs) such as apigenin (major bioactive compound in parsley) might yield clinically useful disease- modifying effect for these neurodegenerative disorders. The present study aimed to investigate the therapeutic effect of apigenin on neuroinflammation in the glial fibrillary acidic protein-interleukin 6 (GFAPIL6) expressing mouse using both immunohistochemical and behavioral tests.

KW - apigenin

KW - anti-inflammatory agents

KW - Alzheimer's disease

KW - cytokines

KW - parsley

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:44469

U2 - 10.1016/j.freeradbiomed.2017.04.064

DO - 10.1016/j.freeradbiomed.2017.04.064

M3 - Conference Paper

SP - S10-S10

BT - Free Radical Biology and Medicine. Volume 108, Supplement 1: Abstracts of the OCC World Congress and Annual SFRR-E Conference 2017: Metabolic Stress and Redox Regulation, Berlin, Germany, 21-23 June 2017

PB - Elsevier

T2 - Oxygen Club of California. World Congress

Y2 - 1 January 2017

ER -

Liang H, Sonego S, Gyengesi E, Rangel A, Niedermayer G , Karl T et al. Anti-inflammatory and neuroprotective effect of apigenin : studies in the GFAP-IL6 mouse model of chronic neuroinflammation. In Free Radical Biology and Medicine. Volume 108, Supplement 1: Abstracts of the OCC World Congress and Annual SFRR-E Conference 2017: Metabolic Stress and Redox Regulation, Berlin, Germany, 21-23 June 2017. Elsevier. 2017. p. S10-S10 doi: 10.1016/j.freeradbiomed.2017.04.064

Anti-inflammatory and neuroprotective effect of apigenin : studies in the GFAP-IL6 mouse model of chronic neuroinflammation

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