Anti-melanin antibodies are increased in sera in Parkinson's disease

K. L. Double; D. B. Rowe; F. M. Carew-Jones; M. Hayes; D. K. Y. Chan; J. Blackie; A. Corbett; R. Joffe; V. S. Fung; J. Morris; P. Riederer; M. Gerlach; G. M. Halliday

doi:10.1016/j.expneurol.2009.03.002

Anti-melanin antibodies are increased in sera in Parkinson's disease

K. L. Double, D. B. Rowe, F. M. Carew-Jones, M. Hayes, D. K. Y. Chan, J. Blackie, A. Corbett, R. Joffe, V. S. Fung, J. Morris, P. Riederer, M. Gerlach, G. M. Halliday

Research output: Contribution to journal › Article › peer-review

Abstract

An increasing body of research suggests that a number of immune mechanisms play a role in degenerative pathways in Parkinson's disease (PD). In the current work we investigated a posited humoral immune response in this disorder. Sera from PD patients exhibited a significantly enhanced absorbance response on a novel ELISA for anti-melanin antibodies, compared to sera from age-matched control subjects. The enhanced ELISA absorbance response was specific for catecholamine-based melanins and was unrelated to antiparkinsonian dopaminergic medication. Further, the absorbance response was significantly and negatively correlated with disease duration. These data suggest that a specific humoral anti-melanin antibody response is present in PD and is more active in early disease. While the contribution of this novel immune response to the initiation and progression of this disorder is unclear, this finding supports the hypothesis that specific immune responses occurring in PD may respond to therapeutic interventions in this disorder.

Original language	English
Pages (from-to)	297-301
Number of pages	5
Journal	Experimental Neurology
Volume	217
Issue number	2
DOIs	https://doi.org/10.1016/j.expneurol.2009.03.002
Publication status	Published - 2009

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title = "Anti-melanin antibodies are increased in sera in Parkinson's disease",

abstract = "An increasing body of research suggests that a number of immune mechanisms play a role in degenerative pathways in Parkinson's disease (PD). In the current work we investigated a posited humoral immune response in this disorder. Sera from PD patients exhibited a significantly enhanced absorbance response on a novel ELISA for anti-melanin antibodies, compared to sera from age-matched control subjects. The enhanced ELISA absorbance response was specific for catecholamine-based melanins and was unrelated to antiparkinsonian dopaminergic medication. Further, the absorbance response was significantly and negatively correlated with disease duration. These data suggest that a specific humoral anti-melanin antibody response is present in PD and is more active in early disease. While the contribution of this novel immune response to the initiation and progression of this disorder is unclear, this finding supports the hypothesis that specific immune responses occurring in PD may respond to therapeutic interventions in this disorder.",

author = "Double, {K. L.} and Rowe, {D. B.} and Carew-Jones, {F. M.} and M. Hayes and Chan, {D. K. Y.} and J. Blackie and A. Corbett and R. Joffe and Fung, {V. S.} and J. Morris and P. Riederer and M. Gerlach and Halliday, {G. M.}",

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doi = "10.1016/j.expneurol.2009.03.002",

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pages = "297--301",

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TY - JOUR

T1 - Anti-melanin antibodies are increased in sera in Parkinson's disease

AU - Double, K. L.

AU - Rowe, D. B.

AU - Carew-Jones, F. M.

AU - Hayes, M.

AU - Chan, D. K. Y.

AU - Blackie, J.

AU - Corbett, A.

AU - Joffe, R.

AU - Fung, V. S.

AU - Morris, J.

AU - Riederer, P.

AU - Gerlach, M.

AU - Halliday, G. M.

PY - 2009

Y1 - 2009

N2 - An increasing body of research suggests that a number of immune mechanisms play a role in degenerative pathways in Parkinson's disease (PD). In the current work we investigated a posited humoral immune response in this disorder. Sera from PD patients exhibited a significantly enhanced absorbance response on a novel ELISA for anti-melanin antibodies, compared to sera from age-matched control subjects. The enhanced ELISA absorbance response was specific for catecholamine-based melanins and was unrelated to antiparkinsonian dopaminergic medication. Further, the absorbance response was significantly and negatively correlated with disease duration. These data suggest that a specific humoral anti-melanin antibody response is present in PD and is more active in early disease. While the contribution of this novel immune response to the initiation and progression of this disorder is unclear, this finding supports the hypothesis that specific immune responses occurring in PD may respond to therapeutic interventions in this disorder.

AB - An increasing body of research suggests that a number of immune mechanisms play a role in degenerative pathways in Parkinson's disease (PD). In the current work we investigated a posited humoral immune response in this disorder. Sera from PD patients exhibited a significantly enhanced absorbance response on a novel ELISA for anti-melanin antibodies, compared to sera from age-matched control subjects. The enhanced ELISA absorbance response was specific for catecholamine-based melanins and was unrelated to antiparkinsonian dopaminergic medication. Further, the absorbance response was significantly and negatively correlated with disease duration. These data suggest that a specific humoral anti-melanin antibody response is present in PD and is more active in early disease. While the contribution of this novel immune response to the initiation and progression of this disorder is unclear, this finding supports the hypothesis that specific immune responses occurring in PD may respond to therapeutic interventions in this disorder.

UR - http://handle.uws.edu.au:8081/1959.7/533195

U2 - 10.1016/j.expneurol.2009.03.002

DO - 10.1016/j.expneurol.2009.03.002

M3 - Article

SN - 0014-4886

VL - 217

SP - 297

EP - 301

JO - Experimental Neurology

JF - Experimental Neurology

IS - 2

ER -

Anti-melanin antibodies are increased in sera in Parkinson's disease

Abstract

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