TY - JOUR
T1 - Antimycobacterial activity and possible mode of action of newly isolated neodiospyrin and other naphthoquinones from Euclea natalensis
AU - Van der Kooy, F.
AU - Meyer, J. J. M.
AU - Lall, N.
PY - 2006
Y1 - 2006
N2 - The roots of Euclea natalensis are used by the indigenous people of southern Africa against various bacterial infections. Six naphthoquinones; diospyrin, isodiospyrin, mamegakinone, 7-methyljuglone, neodiospyrin and shinanolone were isolated from root extracts of this plant. In the case of neodiospyrin, this was a first time isolate. The activity of the six isolated compounds were tested against Mycobacterium tuberculosis using the radiometric BACTEC assay, providing a first report on the antimycobacterial activity of isodiospyrin, neodiospyrin and mamegakinone. The MIC values of diospyrin (8.0 μg/ml), isodiospyrin (10.0 μg/ml), 7-methyljuglone (0.5 μg/ml) and neodiospyrin (10.0 μg/ml) compared well to those of the known antimycobacterial drugs, ethambutol, isoniazid and rifampicin. A hypothesis on the structure-activity relationship for the naphthoquinones and a possible mode of action is discussed.
AB - The roots of Euclea natalensis are used by the indigenous people of southern Africa against various bacterial infections. Six naphthoquinones; diospyrin, isodiospyrin, mamegakinone, 7-methyljuglone, neodiospyrin and shinanolone were isolated from root extracts of this plant. In the case of neodiospyrin, this was a first time isolate. The activity of the six isolated compounds were tested against Mycobacterium tuberculosis using the radiometric BACTEC assay, providing a first report on the antimycobacterial activity of isodiospyrin, neodiospyrin and mamegakinone. The MIC values of diospyrin (8.0 μg/ml), isodiospyrin (10.0 μg/ml), 7-methyljuglone (0.5 μg/ml) and neodiospyrin (10.0 μg/ml) compared well to those of the known antimycobacterial drugs, ethambutol, isoniazid and rifampicin. A hypothesis on the structure-activity relationship for the naphthoquinones and a possible mode of action is discussed.
UR - http://handle.uws.edu.au:8081/1959.7/528518
U2 - 10.1016/j.sajb.2005.09.009
DO - 10.1016/j.sajb.2005.09.009
M3 - Article
SN - 0254-6299
VL - 72
SP - 349
EP - 352
JO - South African Journal of Botany
JF - South African Journal of Botany
IS - 3
ER -