Antioxidant activity in Australian native sarsaparilla (Smilax glyciphylla)

Sean Cox; K. Chamila Jayasinghe; Julie Markham

Antioxidant activity in Australian native sarsaparilla (Smilax glyciphylla)

Sean Cox, K. Chamila Jayasinghe, Julie Markham

Research output: Contribution to journal › Article

38 Citations (Scopus)

Abstract

A hot water extract of the Australian native sarsaparilla Smilax glyciphylla Sm. (Smilaceae) inhibited peroxidation of phosphatidylcholine liposomes initiated by Fe2+/ascorbate (IC50-, 10 Ãƒ"¦Ã‚Â³g/mL) and AAPH (IC50-, 33 Ãƒ"¦Ã‚Â³g/mL) in vitro. It also inhibited deoxyribose degradation and quenched chemically generated superoxide anion (IC50-, 50 Ãƒ"¦Ã‚Â³g/mL). Reactivity towards ABTS (2,2ÃƒÆ’Ã†'Ãƒ"šÃ¢â‚¬Å¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒ"šÃ‚Â´-azinobis(3-ethylbenzothiazoline 6-sulphonate) radical cation was equivalent to 48.4mM TROLOX, the water soluble ÃƒÅ½Ã‚Â±-tocopherol analogue. Smilax glyciphylla is a rich source of the dihydrochalcone glycyphyllin. Given the reported level of activity it is unlikely that glycyphyllin would provide direct antioxidant protection in tissues affected by oxidative stress. However, consuming Smilax glyciphylla as a tea may be sufficient to reduce oxidative damage in the gastrointestinal tract. It is also possible that glycyphyllin is metabolised and adsorbed as phloretin, a compound with known anticancer properties. These findings indicate that further studies of the chemopreventative properties of Smilax glyciphylla is warranted.

Original language	English
Number of pages	7
Journal	Journal of Ethnopharmacology
Publication status	Published - 2005

Keywords

Australia
Sarsaparilla
Smilax glyciphylla
antioxidants
gastrointestinal system
oxidative stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "A hot water extract of the Australian native sarsaparilla Smilax glyciphylla Sm. (Smilaceae) inhibited peroxidation of phosphatidylcholine liposomes initiated by Fe2+/ascorbate (IC50-, 10 {\~A}ƒ{"}¦{\~A}‚{\^A}³g/mL) and AAPH (IC50-, 33 {\~A}ƒ{"}¦{\~A}‚{\^A}³g/mL) in vitro. It also inhibited deoxyribose degradation and quenched chemically generated superoxide anion (IC50-, 50 {\~A}ƒ{"}¦{\~A}‚{\^A}³g/mL). Reactivity towards ABTS (2,2{\~A}ƒ{\AE}{\textquoteright}{\~A}†'{\~A}ƒ{"}{\v s}{\~A}¢{\^a}‚¬{\AA}¡{\~A}ƒ{\AE}{\textquoteright}{\~A}¢{\^a}‚¬{\AA}¡{\~A}ƒ{"}{\v s}{\~A}‚{\^A}´-azinobis(3-ethylbenzothiazoline 6-sulphonate) radical cation was equivalent to 48.4mM TROLOX, the water soluble {\~A}ƒ{\AA}½{\~A}‚{\^A}±-tocopherol analogue. Smilax glyciphylla is a rich source of the dihydrochalcone glycyphyllin. Given the reported level of activity it is unlikely that glycyphyllin would provide direct antioxidant protection in tissues affected by oxidative stress. However, consuming Smilax glyciphylla as a tea may be sufficient to reduce oxidative damage in the gastrointestinal tract. It is also possible that glycyphyllin is metabolised and adsorbed as phloretin, a compound with known anticancer properties. These findings indicate that further studies of the chemopreventative properties of Smilax glyciphylla is warranted.",

keywords = "Australia, Sarsaparilla, Smilax glyciphylla, antioxidants, gastrointestinal system, oxidative stress",

author = "Sean Cox and Jayasinghe, {K. Chamila} and Julie Markham",

year = "2005",

language = "English",

journal = "Journal of Ethnopharmacology",

issn = "0378-8741",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Antioxidant activity in Australian native sarsaparilla (Smilax glyciphylla)

AU - Cox, Sean

AU - Jayasinghe, K. Chamila

AU - Markham, Julie

PY - 2005

Y1 - 2005

N2 - A hot water extract of the Australian native sarsaparilla Smilax glyciphylla Sm. (Smilaceae) inhibited peroxidation of phosphatidylcholine liposomes initiated by Fe2+/ascorbate (IC50-, 10 Ãƒ"¦Ã‚Â³g/mL) and AAPH (IC50-, 33 Ãƒ"¦Ã‚Â³g/mL) in vitro. It also inhibited deoxyribose degradation and quenched chemically generated superoxide anion (IC50-, 50 Ãƒ"¦Ã‚Â³g/mL). Reactivity towards ABTS (2,2ÃƒÆ’Ã†'Ãƒ"šÃ¢â‚¬Å¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒ"šÃ‚Â´-azinobis(3-ethylbenzothiazoline 6-sulphonate) radical cation was equivalent to 48.4mM TROLOX, the water soluble ÃƒÅ½Ã‚Â±-tocopherol analogue. Smilax glyciphylla is a rich source of the dihydrochalcone glycyphyllin. Given the reported level of activity it is unlikely that glycyphyllin would provide direct antioxidant protection in tissues affected by oxidative stress. However, consuming Smilax glyciphylla as a tea may be sufficient to reduce oxidative damage in the gastrointestinal tract. It is also possible that glycyphyllin is metabolised and adsorbed as phloretin, a compound with known anticancer properties. These findings indicate that further studies of the chemopreventative properties of Smilax glyciphylla is warranted.

AB - A hot water extract of the Australian native sarsaparilla Smilax glyciphylla Sm. (Smilaceae) inhibited peroxidation of phosphatidylcholine liposomes initiated by Fe2+/ascorbate (IC50-, 10 Ãƒ"¦Ã‚Â³g/mL) and AAPH (IC50-, 33 Ãƒ"¦Ã‚Â³g/mL) in vitro. It also inhibited deoxyribose degradation and quenched chemically generated superoxide anion (IC50-, 50 Ãƒ"¦Ã‚Â³g/mL). Reactivity towards ABTS (2,2ÃƒÆ’Ã†'Ãƒ"šÃ¢â‚¬Å¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒ"šÃ‚Â´-azinobis(3-ethylbenzothiazoline 6-sulphonate) radical cation was equivalent to 48.4mM TROLOX, the water soluble ÃƒÅ½Ã‚Â±-tocopherol analogue. Smilax glyciphylla is a rich source of the dihydrochalcone glycyphyllin. Given the reported level of activity it is unlikely that glycyphyllin would provide direct antioxidant protection in tissues affected by oxidative stress. However, consuming Smilax glyciphylla as a tea may be sufficient to reduce oxidative damage in the gastrointestinal tract. It is also possible that glycyphyllin is metabolised and adsorbed as phloretin, a compound with known anticancer properties. These findings indicate that further studies of the chemopreventative properties of Smilax glyciphylla is warranted.

KW - Australia

KW - Sarsaparilla

KW - Smilax glyciphylla

KW - antioxidants

KW - gastrointestinal system

KW - oxidative stress

UR - http://handle.uws.edu.au:8081/1959.7/40368

M3 - Article

SN - 0378-8741

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

ER -

Antioxidant activity in Australian native sarsaparilla (Smilax glyciphylla)

Abstract

Keywords

UN SDGs

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