Antioxidant properties of macrophages toward low-density lipoprotein

Anna Baoutina, Roger T. Dean, Wendy K. Jessup

    Research output: Contribution to journalArticle

    Abstract

    Oxidative modification of low-density lipoprotein (LDL) has been implicated in atherosclerosis. Intensive scientific efforts over the last two decades have focused on the elucidation of the mechanisms by which LDL is oxidized in vivo. A wealth of in vitro studies has demonstrated that the cell types present in atherosclerotic lesions, including monocyte/macrophages, quantitatively one of the most important cell types in plaque development, promote LDL oxidation. The mechanisms of cellular prooxidant activities have been extensively investigated. Fewer studies have addressed possible protective properties of the cells in LDL oxidation. This review summarizes recent observations of antioxidant, and potentially antiatherogenic, activities of macrophages toward LDL, including macrophage-mediated detoxification of lipid and protein hydroperoxides, metal sequestration and the generation of compounds with antioxidant properties. These activities could contribute to the net effect of macrophages on deleterious LDL oxidation and to the complex role of these cells in lesion development.
    Original languageEnglish
    Number of pages7
    JournalTrends in Cardiovascular Medicine
    DOIs
    Publication statusPublished - 2001

    Open Access - Access Right Statement

    ©2001, Elsevier Science Inc.

    Keywords

    • atherosclerosis
    • cells
    • lipoproteins
    • low density lipoproteins
    • macrophages
    • oxidation

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