Abstract
In this chapter we describe the use of fluorescence spectroscopy and confocal microscopy to investigate the DNA binding capacity, uptake route and intracellular localisation of novel metallointercalators. Fluorescence is the property whereby some atoms or molecules absorb UV or visible light and then re-emit it at longer wavelengths after a brief interval, termed the fluorescence lifetime.
Original language | English |
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Title of host publication | Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules |
Editors | Janice R. Aldrich-Wright |
Place of Publication | U.S. |
Publisher | Springer |
Pages | 235-272 |
Number of pages | 38 |
ISBN (Electronic) | 9783211990797 |
ISBN (Print) | 9783211094273 |
DOIs | |
Publication status | Published - 2011 |