TY - JOUR
T1 - Aptamers as theranostic agents : modifications, serum stability and functionalisation
AU - Shigdar, Sarah
AU - Macdonald, Joanna
AU - O'Connor, Michael
AU - Wang, Tao
AU - Xiang, Dongxi
AU - Al.Shamaileh, Hadi
AU - Qiao, Liang
AU - Wei, Ning
AU - Zhou, Shu-Feng
AU - Zhu, Yimin
AU - Kong, Lingxue
AU - Bhattacharya, Santanu
AU - Li, ChunGuang
AU - Duan, Wei
PY - 2013
Y1 - 2013
N2 - Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
AB - Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
UR - http://handle.uws.edu.au:8081/1959.7/533530
UR - http://www.mdpi.com/1424-8220/13/10/13624
U2 - 10.3390/s131013624
DO - 10.3390/s131013624
M3 - Article
SN - 1424-8220
VL - 13
SP - 13624
EP - 13737
JO - Sensors
JF - Sensors
IS - 10
ER -
