Aptamers as theranostic agents : modifications, serum stability and functionalisation

Sarah Shigdar; Joanna Macdonald; Michael O&apos;Connor; Tao Wang; Dongxi Xiang; Hadi Al.Shamaileh; Liang Qiao; Ning Wei; Shu-Feng Zhou; Yimin Zhu; Lingxue Kong; Santanu Bhattacharya; ChunGuang Li; Wei Duan

doi:10.3390/s131013624

Aptamers as theranostic agents : modifications, serum stability and functionalisation

Sarah Shigdar
, Joanna Macdonald
, Michael O'Connor
, Tao Wang
, Dongxi Xiang
, Hadi Al.Shamaileh
, Liang Qiao
, Ning Wei
, Shu-Feng Zhou
, Yimin Zhu
, Lingxue Kong
, Santanu Bhattacharya
, ChunGuang Li
, Wei Duan

Research output: Contribution to journal › Article › peer-review

118 Citations (Scopus)

Abstract

Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.

Original language	English
Pages (from-to)	13624-13737
Number of pages	15
Journal	Sensors
Volume	13
Issue number	10
DOIs	https://doi.org/10.3390/s131013624
Publication status	Published - 2013

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.3390/s131013624

Cite this

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abstract = "Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.",

author = "Sarah Shigdar and Joanna Macdonald and Michael O\'Connor and Tao Wang and Dongxi Xiang and Hadi Al.Shamaileh and Liang Qiao and Ning Wei and Shu-Feng Zhou and Yimin Zhu and Lingxue Kong and Santanu Bhattacharya and ChunGuang Li and Wei Duan",

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T1 - Aptamers as theranostic agents : modifications, serum stability and functionalisation

AU - Shigdar, Sarah

AU - Macdonald, Joanna

AU - O'Connor, Michael

AU - Wang, Tao

AU - Xiang, Dongxi

AU - Al.Shamaileh, Hadi

AU - Qiao, Liang

AU - Wei, Ning

AU - Zhou, Shu-Feng

AU - Zhu, Yimin

AU - Kong, Lingxue

AU - Bhattacharya, Santanu

AU - Li, ChunGuang

AU - Duan, Wei

PY - 2013

Y1 - 2013

N2 - Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.

AB - Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.

UR - http://handle.uws.edu.au:8081/1959.7/533530

UR - http://www.mdpi.com/1424-8220/13/10/13624

U2 - 10.3390/s131013624

DO - 10.3390/s131013624

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C2 - 24152925

SN - 1424-8220

VL - 13

SP - 13624

EP - 13737

JO - Sensors

JF - Sensors

IS - 10

ER -

Aptamers as theranostic agents : modifications, serum stability and functionalisation

Abstract

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