Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.

Zeinab G. Khalil; Ritesh Raju; Andrew M. Piggott; Angela A. Salim; Antje Blumenthal; Robert J. Capon

doi:10.1021/acs.jnatprod.5b00095

Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.

Zeinab G. Khalil
, Ritesh Raju
, Andrew M. Piggott
, Angela A. Salim
, Antje Blumenthal
, Robert J. Capon

School of Medicine

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 1-4, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC50 >30 Î¼M) and exhibited moderate and selective cytotoxicity against Gram-positive bacteria (IC50 >1.1 Î¼M) and a panel of human cancer cell lines (IC50 > 7.5 Î¼M). Significantly, 1-4 were cytotoxic (IC50 0.7-1.7 Î¼M) against the Mycobacterium tuberculosis surrogate M. bovis bacille Calmette-GuÃ©rin.

Original language	English
Pages (from-to)	949-952
Number of pages	4
Journal	Journal of Natural Products
Volume	78
Issue number	4
DOIs	https://doi.org/10.1021/acs.jnatprod.5b00095
Publication status	Published - 24 Apr 2015

Bibliographical note

Publisher Copyright:
© 2015 The American Chemical Society and American Society of Pharmacognosy.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

infectious diseases
mycobacteria
tuberculosis

Access to Document

10.1021/acs.jnatprod.5b00095

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title = "Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.",

abstract = "Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 1-4, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC50 >30 {\^I}¼M) and exhibited moderate and selective cytotoxicity against Gram-positive bacteria (IC50 >1.1 {\^I}¼M) and a panel of human cancer cell lines (IC50 > 7.5 {\^I}¼M). Significantly, 1-4 were cytotoxic (IC50 0.7-1.7 {\^I}¼M) against the Mycobacterium tuberculosis surrogate M. bovis bacille Calmette-Gu{\~A}{\textcopyright}rin.",

keywords = "infectious diseases, mycobacteria, tuberculosis",

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note = "Publisher Copyright: {\textcopyright} 2015 The American Chemical Society and American Society of Pharmacognosy.",

year = "2015",

month = apr,

day = "24",

doi = "10.1021/acs.jnatprod.5b00095",

language = "English",

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T1 - Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.

AU - Khalil, Zeinab G.

AU - Raju, Ritesh

AU - Piggott, Andrew M.

AU - Salim, Angela A.

AU - Blumenthal, Antje

AU - Capon, Robert J.

PY - 2015/4/24

Y1 - 2015/4/24

N2 - Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 1-4, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC50 >30 Î¼M) and exhibited moderate and selective cytotoxicity against Gram-positive bacteria (IC50 >1.1 Î¼M) and a panel of human cancer cell lines (IC50 > 7.5 Î¼M). Significantly, 1-4 were cytotoxic (IC50 0.7-1.7 Î¼M) against the Mycobacterium tuberculosis surrogate M. bovis bacille Calmette-GuÃ©rin.

AB - Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 1-4, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC50 >30 Î¼M) and exhibited moderate and selective cytotoxicity against Gram-positive bacteria (IC50 >1.1 Î¼M) and a panel of human cancer cell lines (IC50 > 7.5 Î¼M). Significantly, 1-4 were cytotoxic (IC50 0.7-1.7 Î¼M) against the Mycobacterium tuberculosis surrogate M. bovis bacille Calmette-GuÃ©rin.

KW - infectious diseases

KW - mycobacteria

KW - tuberculosis

UR - http://handle.uws.edu.au:8081/1959.7/uws:32736

U2 - 10.1021/acs.jnatprod.5b00095

DO - 10.1021/acs.jnatprod.5b00095

M3 - Article

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SN - 0163-3864

VL - 78

SP - 949

EP - 952

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.

Abstract

Bibliographical note

UN SDGs

Keywords

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