Assessing the Clinical Effectiveness of Radioimmunotherapy with Combined Radionuclide/Monoclonal Antibody Conjugates in Cancer Treatment: Insights from Randomised Clinical Trials

This is the first meta-analysis to assess the effectiveness of radioimmunotherapy (RIT) for various cancers by including only randomised controlled trial study designs. The inclusion of 20 clinical trials with a total of 3562 patients assigned to 10 different RITs covers the last 20 years of RIT research in seven types of cancer (including non-solid and solid tumours). Our analysis presents a comprehensive evaluation of the efficacy and safety profiles of various cancer treatments based on a synthesis of direct and indirect evidence derived from the included trials and an investigation of different patient subgroups. Our analysis provided an in-depth focus on the most commonly used RIT, the most common cancer types treated by RIT, and the patient population that has been treated with RIT. This allowed us to contextualise and identify potential directions for optimising cancer treatment regimens and future RIT development.