Assessment of effective absorbed dose of 111in-DTPA-buserelin in human on the basis of biodistribution rat data

Afsaneh Lahooti; S. Shanehsazzadeh; A. R. Jalilian; M. B. Tavakoli

doi:10.1093/rpd/ncs137

Assessment of effective absorbed dose of 111in-DTPA-buserelin in human on the basis of biodistribution rat data

Afsaneh Lahooti, S. Shanehsazzadeh, A. R. Jalilian, M. B. Tavakoli

Western Sydney University

Research output: Contribution to journal › Article › peer-review

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Abstract

In this study, the effective absorbed dose to human organs was estimated, following intra vascular administration of 111In-DTPA-Buserelin using biodistribution data from rats. Rats were sacrificed at exact time intervals of 0.25, 0.5, 1, 2, 4 and 24 h post injections. The Medical Internal Radiation Dose formulation was applied to extrapolate from rats to humans and to project the absorbed radiation dose for various human organs. From rat data, it was estimated that a 185-MBq injection of 111In-DTPA-Buserelin into the human might result in an estimated absorbed dose of 24.27 mGy to the total body and the highest effective absorbed dose was in kidneys, 28.39 mSv. The promising results of this study emphasises the importance of absorbed doses in humans estimated from data on rats.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Radiation Protection Dosimetry
Volume	154
Issue number	1
DOIs	https://doi.org/10.1093/rpd/ncs137
Publication status	Published - 2013

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AU - Lahooti, Afsaneh

AU - Shanehsazzadeh, S.

AU - Jalilian, A. R.

AU - Tavakoli, M. B.

PY - 2013

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AB - In this study, the effective absorbed dose to human organs was estimated, following intra vascular administration of 111In-DTPA-Buserelin using biodistribution data from rats. Rats were sacrificed at exact time intervals of 0.25, 0.5, 1, 2, 4 and 24 h post injections. The Medical Internal Radiation Dose formulation was applied to extrapolate from rats to humans and to project the absorbed radiation dose for various human organs. From rat data, it was estimated that a 185-MBq injection of 111In-DTPA-Buserelin into the human might result in an estimated absorbed dose of 24.27 mGy to the total body and the highest effective absorbed dose was in kidneys, 28.39 mSv. The promising results of this study emphasises the importance of absorbed doses in humans estimated from data on rats.

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DO - 10.1093/rpd/ncs137

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JF - Radiation Protection Dosimetry

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Assessment of effective absorbed dose of 111in-DTPA-buserelin in human on the basis of biodistribution rat data

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