TY - JOUR
T1 - Assessment of the effective absorbed dose of 4-benzyl-1-(3-[125I]-iodobenzylsulfonyl)piperidine in humans on the basis of biodistribution data of rats
AU - Sadeghzadeh, M.
AU - Shanehsazzadeh, S.
AU - Lahooti, Afsaneh
PY - 2015
Y1 - 2015
N2 - Objectives: The aim of this study was to estimate the effective absorbed radiation dose to human organs following promising in-vivo results of intravenous administration of 4-benzyl-1-(3-[125I]-iodobenzylsulfonyl) piperidine (4-B-[125I]-IBSP) using normal biodistribution data obtained from rats. Materials and methods: Five rats were killed at exact time intervals and the percentage of injected dose per gram of each organ was measured by direct counting from rat data. The medical internal radiation dose formulation was applied to extrapolate from rats to humans and to project the absorbed radiation dose for various human organs. Results: The dose estimation shows that the organs that received the highest absorbed dose were the brain, bone surface, and red marrow (10.51, 0.69, and 0.08 μGy/MBq, respectively). Our prediction shows that a 185MBq injection of 4-B-[125I]-IBSP into humans might result in an estimated absorbed dose of 49.39 μGy for the whole body. The highest effective absorbed dose for 4-B-[125I]-IBSP was in the brain (19.4 μSv) and the organs that received the next highest doses were the bone surface, red marrow, muscle, and thyroid, with magnitudes of 15.27, 1.81, 0.15, and 0.10 μSv, respectively. Conclusion: The results of this study suggest that 4-B- [125I]-IBSP is a suitable and safe candidate in clinical studies and in lung malignancies.
AB - Objectives: The aim of this study was to estimate the effective absorbed radiation dose to human organs following promising in-vivo results of intravenous administration of 4-benzyl-1-(3-[125I]-iodobenzylsulfonyl) piperidine (4-B-[125I]-IBSP) using normal biodistribution data obtained from rats. Materials and methods: Five rats were killed at exact time intervals and the percentage of injected dose per gram of each organ was measured by direct counting from rat data. The medical internal radiation dose formulation was applied to extrapolate from rats to humans and to project the absorbed radiation dose for various human organs. Results: The dose estimation shows that the organs that received the highest absorbed dose were the brain, bone surface, and red marrow (10.51, 0.69, and 0.08 μGy/MBq, respectively). Our prediction shows that a 185MBq injection of 4-B-[125I]-IBSP into humans might result in an estimated absorbed dose of 49.39 μGy for the whole body. The highest effective absorbed dose for 4-B-[125I]-IBSP was in the brain (19.4 μSv) and the organs that received the next highest doses were the bone surface, red marrow, muscle, and thyroid, with magnitudes of 15.27, 1.81, 0.15, and 0.10 μSv, respectively. Conclusion: The results of this study suggest that 4-B- [125I]-IBSP is a suitable and safe candidate in clinical studies and in lung malignancies.
UR - https://hdl.handle.net/1959.7/uws:76315
U2 - 10.1097/MNM.0000000000000210
DO - 10.1097/MNM.0000000000000210
M3 - Article
SN - 0143-3636
VL - 36
SP - 90
EP - 94
JO - Nuclear Medicine Communications
JF - Nuclear Medicine Communications
IS - 1
ER -