TY - JOUR
T1 - Associations between uric acid and depressive symptoms, and the mediating role of immunoinflammatory
T2 - findings from rural older adults
AU - Luo, Yating
AU - Wang, Sha
AU - Cheng, Qinqin
AU - Li, Jing
AU - Zhang, Huiyi
AU - Wang, Jingying
AU - Luo, Juan
AU - Pan, Chen
AU - Zhang, Qiuxiang
AU - Xie, Jianfei
AU - Cheng, Andy S.K.
N1 - Publisher Copyright:
© The Authors
PY - 2024/12
Y1 - 2024/12
N2 - Background: In the low-resource rural areas, older adults may experience prolonged and severe depressive symptoms. This study aimed to investigate the relationship between uric acid, depressive symptoms and immunoinflammatory among rural older adults. Method: This case-control study was conducted in 17 rural villages in Hunan Province, China, between January 2023 and April 2024. This study included 180 participants: (1) Rural Older Adults with Depressive Symptoms group:90 patients with first-time diagnosed with depressive symptoms (Geriatric Depression Scale-15, GDS-15 ≥ 5 scores); (2) Control group: 90 individually matched (age and sex) healthy subjects (GDS-15 < 5 scores) who were aged ≥60 years. Results: Both males and females, depressive symptoms were associated with higher uric acid levels and C-reactive protein levels (All P < 0.05). Whereas in females, depressive symptoms were also linked to higher procalcitonin (P = 0.005) and serum amyloid A (P = 0.008) levels. In addition, C-reactive protein plays a significant mediating role between uric acid and depressive symptoms in males. Conclusion: Further investigation is necessary to clarify the underlying mechanisms, examine gender-specific disparities, and assess potential therapeutic interventions targeting uric acid and inflammation levels to mitigate mental disorders risk.
AB - Background: In the low-resource rural areas, older adults may experience prolonged and severe depressive symptoms. This study aimed to investigate the relationship between uric acid, depressive symptoms and immunoinflammatory among rural older adults. Method: This case-control study was conducted in 17 rural villages in Hunan Province, China, between January 2023 and April 2024. This study included 180 participants: (1) Rural Older Adults with Depressive Symptoms group:90 patients with first-time diagnosed with depressive symptoms (Geriatric Depression Scale-15, GDS-15 ≥ 5 scores); (2) Control group: 90 individually matched (age and sex) healthy subjects (GDS-15 < 5 scores) who were aged ≥60 years. Results: Both males and females, depressive symptoms were associated with higher uric acid levels and C-reactive protein levels (All P < 0.05). Whereas in females, depressive symptoms were also linked to higher procalcitonin (P = 0.005) and serum amyloid A (P = 0.008) levels. In addition, C-reactive protein plays a significant mediating role between uric acid and depressive symptoms in males. Conclusion: Further investigation is necessary to clarify the underlying mechanisms, examine gender-specific disparities, and assess potential therapeutic interventions targeting uric acid and inflammation levels to mitigate mental disorders risk.
KW - Depressive symptoms
KW - Immunoinflammatory
KW - Rural older adults
KW - Uric acid
UR - http://www.scopus.com/inward/record.url?scp=85207322207&partnerID=8YFLogxK
U2 - 10.1016/j.bbih.2024.100893
DO - 10.1016/j.bbih.2024.100893
M3 - Article
AN - SCOPUS:85207322207
SN - 2666-3546
VL - 42
JO - Brain, Behavior, and Immunity - Health
JF - Brain, Behavior, and Immunity - Health
M1 - 100893
ER -