Austrocolorone B and austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini

Karren D. Beattie; Dion R. Thompson; Evelin Tiralongo; David Ratkowsky; Tom W. May; Melvyn Gill

doi:10.1016/j.tetlet.2011.08.015

Austrocolorone B and austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini

Karren D. Beattie, Dion R. Thompson, Evelin Tiralongo, David Ratkowsky, Tom W. May, Melvyn Gill

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

The yellow dihydroanthracenone dimer, austrocolorin B1 and the unique violet-red 1,4-anthraquinone dimer, austrocolorone B, were isolated from the Tasmanian mushroom Cortinarius vinosipes and their structures and stereochemistry were determined from spectroscopic data. Austrocolorin B 1 and austrocolorone B were found to exhibit potent cytotoxic activity in vitro against the murine lymphoblast (P388D1) cell line with IC50 values in the range 10-31 μg/mL.

Original language	English
Pages (from-to)	5448-5451
Number of pages	4
Journal	Tetrahedron Letters
Volume	52
Issue number	42
DOIs	https://doi.org/10.1016/j.tetlet.2011.08.015
Publication status	Published - 2011

Keywords

Australia
anthraquinones
antineoplastic agents
fungi

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10.1016/j.tetlet.2011.08.015

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title = "Austrocolorone B and austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini",

abstract = "The yellow dihydroanthracenone dimer, austrocolorin B1 and the unique violet-red 1,4-anthraquinone dimer, austrocolorone B, were isolated from the Tasmanian mushroom Cortinarius vinosipes and their structures and stereochemistry were determined from spectroscopic data. Austrocolorin B 1 and austrocolorone B were found to exhibit potent cytotoxic activity in vitro against the murine lymphoblast (P388D1) cell line with IC50 values in the range 10-31 μg/mL.",

keywords = "Australia, anthraquinones, antineoplastic agents, fungi",

author = "Beattie, {Karren D.} and Thompson, {Dion R.} and Evelin Tiralongo and David Ratkowsky and May, {Tom W.} and Melvyn Gill",

year = "2011",

doi = "10.1016/j.tetlet.2011.08.015",

language = "English",

volume = "52",

pages = "5448--5451",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

number = "42",

}

TY - JOUR

T1 - Austrocolorone B and austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini

AU - Beattie, Karren D.

AU - Thompson, Dion R.

AU - Tiralongo, Evelin

AU - Ratkowsky, David

AU - May, Tom W.

AU - Gill, Melvyn

PY - 2011

Y1 - 2011

N2 - The yellow dihydroanthracenone dimer, austrocolorin B1 and the unique violet-red 1,4-anthraquinone dimer, austrocolorone B, were isolated from the Tasmanian mushroom Cortinarius vinosipes and their structures and stereochemistry were determined from spectroscopic data. Austrocolorin B 1 and austrocolorone B were found to exhibit potent cytotoxic activity in vitro against the murine lymphoblast (P388D1) cell line with IC50 values in the range 10-31 μg/mL.

AB - The yellow dihydroanthracenone dimer, austrocolorin B1 and the unique violet-red 1,4-anthraquinone dimer, austrocolorone B, were isolated from the Tasmanian mushroom Cortinarius vinosipes and their structures and stereochemistry were determined from spectroscopic data. Austrocolorin B 1 and austrocolorone B were found to exhibit potent cytotoxic activity in vitro against the murine lymphoblast (P388D1) cell line with IC50 values in the range 10-31 μg/mL.

KW - Australia

KW - anthraquinones

KW - antineoplastic agents

KW - fungi

UR - http://handle.uws.edu.au:8081/1959.7/uws:34155

U2 - 10.1016/j.tetlet.2011.08.015

DO - 10.1016/j.tetlet.2011.08.015

M3 - Article

SN - 0040-4039

VL - 52

SP - 5448

EP - 5451

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 42

ER -

Austrocolorone B and austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini

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Keywords

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