Bacterial phylogeny in the Cayley graph

Chad Clark, Attila Egri-Nagy, Andrew Francis, Volker Gebhardt

Research output: Contribution to journalArticlepeer-review

Abstract

Many models of genome rearrangement involve operations that are self-inverse, and hence generate a group acting on the space of genomes. This gives a correspondence between genome arrangements and the elements of a group, and consequently, between evolutionary paths and walks on the Cayley graph. Many common methods for phylogenetic reconstruction rely on calculating the minimal distance between two genomes; this omits much of the other information available from the Cayley graph. In this paper, we begin an exploration of some of this additional information, in particular describing the phylogeny as a Steiner tree within the Cayley graph, and exploring the "interval" between two genomes. While motivated by problems in systematic biology, many of these ideas are of independent group-theoretic interest.
Original languageEnglish
Article number1950059
Number of pages14
JournalDiscrete Mathematics, Algorithms and Applications
Volume11
Issue number5
DOIs
Publication statusPublished - 2019

Keywords

  • Cayley graphs
  • bacterial genomes
  • mathematical models
  • phylogeny

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