BDNF Val66Met polymorphism is associated with body mass index in healthy adults

John Gunstad; Peter Schofield; Robert H. Paul; Mary Beth Spitznagel; Ronald A. Cohen; Leanne M. Williams; Michael Kohn; Evian Gordon

doi:10.1159/000093341

BDNF Val66Met polymorphism is associated with body mass index in healthy adults

John Gunstad, Peter Schofield, Robert H. Paul, Mary Beth Spitznagel, Ronald A. Cohen, Leanne M. Williams, Michael Kohn, Evian Gordon

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

Although recent studies suggest a possible relationship between the brain-derived neurotrophic factor Val66Met polymorphism and eating disorders, no study has examined the possibility that the Met-Met genotype is associated with a lower body mass index (BMI) in healthy individuals. We examined this possibility in 481 adults (age range 18-82 years) without significant medical or psychiatric history. After adjusting for gender, analysis of covariance showed that persons with the Met-Met genotype had a lower BMI than those with the Val-Met/Val-Val genotypes (22.28 ± 3.77 vs. 24.72 ± 4.81). A similar, though nonsignificant, trend emerged when comparing all three genotypes separately. These findings suggest a possible relationship between Val66Met polymorphism and BMI in healthy adults. Further work is needed to clarify possible mechanisms for this relationship.

Original language	English
Pages (from-to)	153-156
Number of pages	4
Journal	Neuropsychobiology
Volume	53
Issue number	3
DOIs	https://doi.org/10.1159/000093341
Publication status	Published - Jun 2006
Externally published	Yes

Keywords

Brain-derived neurotrophic factor (BDNF)
Obesity
Polymorphism, BDNF

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000093341

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title = "BDNF Val66Met polymorphism is associated with body mass index in healthy adults",

abstract = "Although recent studies suggest a possible relationship between the brain-derived neurotrophic factor Val66Met polymorphism and eating disorders, no study has examined the possibility that the Met-Met genotype is associated with a lower body mass index (BMI) in healthy individuals. We examined this possibility in 481 adults (age range 18-82 years) without significant medical or psychiatric history. After adjusting for gender, analysis of covariance showed that persons with the Met-Met genotype had a lower BMI than those with the Val-Met/Val-Val genotypes (22.28 ± 3.77 vs. 24.72 ± 4.81). A similar, though nonsignificant, trend emerged when comparing all three genotypes separately. These findings suggest a possible relationship between Val66Met polymorphism and BMI in healthy adults. Further work is needed to clarify possible mechanisms for this relationship.",

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T1 - BDNF Val66Met polymorphism is associated with body mass index in healthy adults

AU - Gunstad, John

AU - Schofield, Peter

AU - Paul, Robert H.

AU - Spitznagel, Mary Beth

AU - Cohen, Ronald A.

AU - Williams, Leanne M.

AU - Kohn, Michael

AU - Gordon, Evian

PY - 2006/6

Y1 - 2006/6

N2 - Although recent studies suggest a possible relationship between the brain-derived neurotrophic factor Val66Met polymorphism and eating disorders, no study has examined the possibility that the Met-Met genotype is associated with a lower body mass index (BMI) in healthy individuals. We examined this possibility in 481 adults (age range 18-82 years) without significant medical or psychiatric history. After adjusting for gender, analysis of covariance showed that persons with the Met-Met genotype had a lower BMI than those with the Val-Met/Val-Val genotypes (22.28 ± 3.77 vs. 24.72 ± 4.81). A similar, though nonsignificant, trend emerged when comparing all three genotypes separately. These findings suggest a possible relationship between Val66Met polymorphism and BMI in healthy adults. Further work is needed to clarify possible mechanisms for this relationship.

AB - Although recent studies suggest a possible relationship between the brain-derived neurotrophic factor Val66Met polymorphism and eating disorders, no study has examined the possibility that the Met-Met genotype is associated with a lower body mass index (BMI) in healthy individuals. We examined this possibility in 481 adults (age range 18-82 years) without significant medical or psychiatric history. After adjusting for gender, analysis of covariance showed that persons with the Met-Met genotype had a lower BMI than those with the Val-Met/Val-Val genotypes (22.28 ± 3.77 vs. 24.72 ± 4.81). A similar, though nonsignificant, trend emerged when comparing all three genotypes separately. These findings suggest a possible relationship between Val66Met polymorphism and BMI in healthy adults. Further work is needed to clarify possible mechanisms for this relationship.

KW - Brain-derived neurotrophic factor (BDNF)

KW - Obesity

KW - Polymorphism, BDNF

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JO - Neuropsychobiology

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BDNF Val66Met polymorphism is associated with body mass index in healthy adults

Abstract

Keywords

UN SDGs

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