Abstract
Objective: To determine the effect of n-3 polyunsaturated fatty acids (n-3PUFAs) supplementation on circulatory resistin and monocyte chemoattractant 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients. Subjects and Methods: This was a ten-week, placebo-controlled, double-blind, randomized trial of n-3 PUFAs (2700 mg/day) vs. placebo (soft gels containing 900 mg of edible paraffin). Fortyfour (44) T2DM patients were supplemented with n-3 PUFAs and another 44 patients received placebo (3 patients discontinued the trial). Serum resistin, MCP-1 and lipid profile were measured before and after supplementation. Also, adiponectin-resistin index (1+log10(Resistin)-log10(Adiponectin)) and atherogenic index (log10 triglycerides/HDL-C) of plasma, which is an indicator of cardiovascular complications, were assessed. Independent t-test was used, to access the differences between supplement and placebo groups and the paired t-test was used to analyze the before/after changes. Results: In this study, n-3 PUFAs reduced serum MCP-1 levels (from 260.5 to 230.5 pg/ml; p= 0.002), while remained unchanged in placebo group. On the contrary, n-3 PUFAs could not decrease serum resistin levels. Adiponectin-resistin index was significantly reduced after supplementation with n-3 PUFAs, compared to placebo. The atherogenic index was also significantly improved after supplementation with n-3 PUFAs (from 1.459 to 1.412; p=0.006). Conclusions: The MCP-1 levels and lipid profile were improved after supplementation with n-3 PUFAs, but resistin serum levels were not changed. Hence, the antiinflammatory effects of n-3 PUFAs might be mediated by targeting MCP-1.
Original language | English |
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Pages (from-to) | 535-541 |
Number of pages | 19 |
Journal | Medical Principles and Practice |
Volume | 26 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2018 |
Open Access - Access Right Statement
This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. ©2017The Author(s).Keywords
- cytokines
- diabetes
- fatty acids
- inflammation
- non, insulin, dependent diabetes
- omega, 3 fatty acids