Biodistribution evaluation of 166Ho-DTPA-SPION in normal rats

S. Nosrati; S. Shanehsazzadeh; H. Yousefnia; A. Gholami; C. Grüttner; A. R. Jalilian; R. H. Hosseini; Afsaneh Lahooti

doi:10.1007/s10967-015-4251-x

Biodistribution evaluation of 166Ho-DTPA-SPION in normal rats

S. Nosrati, S. Shanehsazzadeh, H. Yousefnia, A. Gholami, C. Grüttner, A. R. Jalilian, R. H. Hosseini, Afsaneh Lahooti

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Abstract

Super paramagnetic iron oxide nanoparticles (SPION) with a cross-linked dextran coating can be used as a negative contrast agent in magnetic resonance imaging agent. This study describes the preparation, biodistribution of 166Ho-DTPA-SPIONs after intravenous injection in normal Wistar rats. The biodistribution of 166Ho-DTPA-SPIONs showed dramatic uptake in reticuloendothelial system (i.e., more than 60 and 15% of injected dose was in liver and spleen at 30Ã‚ min post-injection, respectively) and the clearance of the radiotracer is so fast in other organs. These results suggest that 166Ho-DTPA-SPIONs could be good candidate for theranostic purposes in for liver and spleen malignancies.

Original language	English
Pages (from-to)	1559-1566
Number of pages	8
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	307
Issue number	2
DOIs	https://doi.org/10.1007/s10967-015-4251-x
Publication status	Published - 2016

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title = "Biodistribution evaluation of 166Ho-DTPA-SPION in normal rats",

abstract = "Super paramagnetic iron oxide nanoparticles (SPION) with a cross-linked dextran coating can be used as a negative contrast agent in magnetic resonance imaging agent. This study describes the preparation, biodistribution of 166Ho-DTPA-SPIONs after intravenous injection in normal Wistar rats. The biodistribution of 166Ho-DTPA-SPIONs showed dramatic uptake in reticuloendothelial system (i.e., more than 60 and 15% of injected dose was in liver and spleen at 30{\~A}‚ min post-injection, respectively) and the clearance of the radiotracer is so fast in other organs. These results suggest that 166Ho-DTPA-SPIONs could be good candidate for theranostic purposes in for liver and spleen malignancies.",

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language = "English",

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T1 - Biodistribution evaluation of 166Ho-DTPA-SPION in normal rats

AU - Nosrati, S.

AU - Shanehsazzadeh, S.

AU - Yousefnia, H.

AU - Gholami, A.

AU - Grüttner, C.

AU - Jalilian, A. R.

AU - Hosseini, R. H.

AU - Lahooti, Afsaneh

PY - 2016

Y1 - 2016

N2 - Super paramagnetic iron oxide nanoparticles (SPION) with a cross-linked dextran coating can be used as a negative contrast agent in magnetic resonance imaging agent. This study describes the preparation, biodistribution of 166Ho-DTPA-SPIONs after intravenous injection in normal Wistar rats. The biodistribution of 166Ho-DTPA-SPIONs showed dramatic uptake in reticuloendothelial system (i.e., more than 60 and 15% of injected dose was in liver and spleen at 30Ã‚ min post-injection, respectively) and the clearance of the radiotracer is so fast in other organs. These results suggest that 166Ho-DTPA-SPIONs could be good candidate for theranostic purposes in for liver and spleen malignancies.

AB - Super paramagnetic iron oxide nanoparticles (SPION) with a cross-linked dextran coating can be used as a negative contrast agent in magnetic resonance imaging agent. This study describes the preparation, biodistribution of 166Ho-DTPA-SPIONs after intravenous injection in normal Wistar rats. The biodistribution of 166Ho-DTPA-SPIONs showed dramatic uptake in reticuloendothelial system (i.e., more than 60 and 15% of injected dose was in liver and spleen at 30Ã‚ min post-injection, respectively) and the clearance of the radiotracer is so fast in other organs. These results suggest that 166Ho-DTPA-SPIONs could be good candidate for theranostic purposes in for liver and spleen malignancies.

UR - https://hdl.handle.net/1959.7/uws:76258

U2 - 10.1007/s10967-015-4251-x

DO - 10.1007/s10967-015-4251-x

M3 - Article

SN - 0236-5731

VL - 307

SP - 1559

EP - 1566

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 2

ER -

Biodistribution evaluation of 166Ho-DTPA-SPION in normal rats

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