Biology of the staphylococcal conjugative multiresistance plasmid pSK41

Michael A. Liu; Stephen M. Kwong; Slade O. Jensen; Anthony J. Brzoska; Neville Firth

doi:10.1016/j.plasmid.2013.02.001

Biology of the staphylococcal conjugative multiresistance plasmid pSK41

Michael A. Liu, Stephen M. Kwong, Slade O. Jensen, Anthony J. Brzoska, Neville Firth

School of Medicine

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29 Citations (Scopus)

Abstract

Plasmid pSK41 is a large, low-copy-number, conjugative plasmid from Staphylococcus aureus that is representative of a family of staphylococcal plasmids that confer multiple resistances to a wide range of antimicrobial agents. The plasmid consists of a conserved plasmid backbone containing the genes for plasmid housekeeping functions, which is punctuated by copies of IS257 that flank a Tn4001-hybrid structure and cointegrated plasmids that harbour resistance genes. This review summarises the current understanding of the biology of pSK41, focussing on the systems responsible for its replication, maintenance and transmission, and their regulation.

Original language	English
Pages (from-to)	42-51
Number of pages	10
Journal	Plasmid
Volume	70
Issue number	1
DOIs	https://doi.org/10.1016/j.plasmid.2013.02.001
Publication status	Published - 2013

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abstract = "Plasmid pSK41 is a large, low-copy-number, conjugative plasmid from Staphylococcus aureus that is representative of a family of staphylococcal plasmids that confer multiple resistances to a wide range of antimicrobial agents. The plasmid consists of a conserved plasmid backbone containing the genes for plasmid housekeeping functions, which is punctuated by copies of IS257 that flank a Tn4001-hybrid structure and cointegrated plasmids that harbour resistance genes. This review summarises the current understanding of the biology of pSK41, focussing on the systems responsible for its replication, maintenance and transmission, and their regulation.",

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AU - Firth, Neville

PY - 2013

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AB - Plasmid pSK41 is a large, low-copy-number, conjugative plasmid from Staphylococcus aureus that is representative of a family of staphylococcal plasmids that confer multiple resistances to a wide range of antimicrobial agents. The plasmid consists of a conserved plasmid backbone containing the genes for plasmid housekeeping functions, which is punctuated by copies of IS257 that flank a Tn4001-hybrid structure and cointegrated plasmids that harbour resistance genes. This review summarises the current understanding of the biology of pSK41, focussing on the systems responsible for its replication, maintenance and transmission, and their regulation.

UR - http://hdl.handle.net/1959.7/uws:20188

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JO - Plasmid

JF - Plasmid

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Biology of the staphylococcal conjugative multiresistance plasmid pSK41

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