Biomimetic recombinant of red blood cell membranes for improved photothermal therapy

Pengkai Wu; Xing Jiang; Shuai Yin; Ying Yang; Tianqing Liu; Kaikai Wang

doi:10.1186/s12951-021-00949-7

Biomimetic recombinant of red blood cell membranes for improved photothermal therapy

Pengkai Wu, Xing Jiang, Shuai Yin, Ying Yang, Tianqing Liu, Kaikai Wang

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Background: RBC membrane derived nanoparticles (NPs) represent an emerging platform with prolonged circulation capacity for the delivery of active substances. For functionalize derived RBCs NPs, various strategies, such as biomimetic rebuilding of RBCs, chemical modification or inserting ligands, have been carried out to improve their performance. However, one potential adverse effect for these methods is the structural failure of membrane proteins, consequently affecting its original immune escape function. Results: In this study, we reported a green technology of "disassembly-reassembly" to prepare biomimetic reconstituted RBCs membrane (rRBCs) by separating the endogenous proteins and lipids from nature RBC membrane. IR780 iodide was used as a pattern drug to verify the property and feasibility of rRBCs by constructing IR780@rRBC NPs with IR780@RBC NPs and free IR780 as controls. The results demonstrated the superiority of IR780@rRBC NPs in toxicity, stability, pharmacokinetics and pharmacodynamics compared with IR780@rRBC and free IR780. Conclusions: The reported "disassembly-reassembly" strategy shows great potential to produce controllable and versatile rRBC membrane-inspired delivery platform, which may be used to overcome the deficiency of functionalization in cell membrane coated nanoparticles. Graphic abstract: [Figure not available: see fulltext.].

Original language	English
Article number	213
Number of pages	13
Journal	Journal of Nanobiotechnology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12951-021-00949-7
Publication status	Published - Dec 2021

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title = "Biomimetic recombinant of red blood cell membranes for improved photothermal therapy",

abstract = "Background: RBC membrane derived nanoparticles (NPs) represent an emerging platform with prolonged circulation capacity for the delivery of active substances. For functionalize derived RBCs NPs, various strategies, such as biomimetic rebuilding of RBCs, chemical modification or inserting ligands, have been carried out to improve their performance. However, one potential adverse effect for these methods is the structural failure of membrane proteins, consequently affecting its original immune escape function. Results: In this study, we reported a green technology of {"}disassembly-reassembly{"} to prepare biomimetic reconstituted RBCs membrane (rRBCs) by separating the endogenous proteins and lipids from nature RBC membrane. IR780 iodide was used as a pattern drug to verify the property and feasibility of rRBCs by constructing IR780@rRBC NPs with IR780@RBC NPs and free IR780 as controls. The results demonstrated the superiority of IR780@rRBC NPs in toxicity, stability, pharmacokinetics and pharmacodynamics compared with IR780@rRBC and free IR780. Conclusions: The reported {"}disassembly-reassembly{"} strategy shows great potential to produce controllable and versatile rRBC membrane-inspired delivery platform, which may be used to overcome the deficiency of functionalization in cell membrane coated nanoparticles. Graphic abstract: [Figure not available: see fulltext.].",

author = "Pengkai Wu and Xing Jiang and Shuai Yin and Ying Yang and Tianqing Liu and Kaikai Wang",

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doi = "10.1186/s12951-021-00949-7",

language = "English",

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T1 - Biomimetic recombinant of red blood cell membranes for improved photothermal therapy

AU - Wu, Pengkai

AU - Jiang, Xing

AU - Yin, Shuai

AU - Yang, Ying

AU - Liu, Tianqing

AU - Wang, Kaikai

PY - 2021/12

Y1 - 2021/12

N2 - Background: RBC membrane derived nanoparticles (NPs) represent an emerging platform with prolonged circulation capacity for the delivery of active substances. For functionalize derived RBCs NPs, various strategies, such as biomimetic rebuilding of RBCs, chemical modification or inserting ligands, have been carried out to improve their performance. However, one potential adverse effect for these methods is the structural failure of membrane proteins, consequently affecting its original immune escape function. Results: In this study, we reported a green technology of "disassembly-reassembly" to prepare biomimetic reconstituted RBCs membrane (rRBCs) by separating the endogenous proteins and lipids from nature RBC membrane. IR780 iodide was used as a pattern drug to verify the property and feasibility of rRBCs by constructing IR780@rRBC NPs with IR780@RBC NPs and free IR780 as controls. The results demonstrated the superiority of IR780@rRBC NPs in toxicity, stability, pharmacokinetics and pharmacodynamics compared with IR780@rRBC and free IR780. Conclusions: The reported "disassembly-reassembly" strategy shows great potential to produce controllable and versatile rRBC membrane-inspired delivery platform, which may be used to overcome the deficiency of functionalization in cell membrane coated nanoparticles. Graphic abstract: [Figure not available: see fulltext.].

AB - Background: RBC membrane derived nanoparticles (NPs) represent an emerging platform with prolonged circulation capacity for the delivery of active substances. For functionalize derived RBCs NPs, various strategies, such as biomimetic rebuilding of RBCs, chemical modification or inserting ligands, have been carried out to improve their performance. However, one potential adverse effect for these methods is the structural failure of membrane proteins, consequently affecting its original immune escape function. Results: In this study, we reported a green technology of "disassembly-reassembly" to prepare biomimetic reconstituted RBCs membrane (rRBCs) by separating the endogenous proteins and lipids from nature RBC membrane. IR780 iodide was used as a pattern drug to verify the property and feasibility of rRBCs by constructing IR780@rRBC NPs with IR780@RBC NPs and free IR780 as controls. The results demonstrated the superiority of IR780@rRBC NPs in toxicity, stability, pharmacokinetics and pharmacodynamics compared with IR780@rRBC and free IR780. Conclusions: The reported "disassembly-reassembly" strategy shows great potential to produce controllable and versatile rRBC membrane-inspired delivery platform, which may be used to overcome the deficiency of functionalization in cell membrane coated nanoparticles. Graphic abstract: [Figure not available: see fulltext.].

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DO - 10.1186/s12951-021-00949-7

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SN - 1477-3155

VL - 19

JO - Journal of Nanobiotechnology

JF - Journal of Nanobiotechnology

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ER -

Biomimetic recombinant of red blood cell membranes for improved photothermal therapy

Abstract

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