Biomolecular ineractions of platinum complexes

Benjamin W. Harper; Feng Li; Rhys Beard; K. Benjamin Garbutcheon-Singh; Neville S. Ng; Janice R. Aldrich-Wright

Biomolecular ineractions of platinum complexes

Benjamin W. Harper, Feng Li, Rhys Beard, K. Benjamin Garbutcheon-Singh, Neville S. Ng, Janice R. Aldrich-Wright

Research output: Chapter in Book / Conference Paper › Chapter

Abstract

![CDATA[The in vitro and in vivo effects of platinum complexes have been well reported. However, it is their interactions with biologically relevant structures and bio-macromolecules such as DNA and proteins that can determine their therapeutic effects. The pharmacological properties of platinum complexes are dependent on binding interactions, and the investigation of such interactions is essential to gain insight into the mechanisms of action. Interactions with DNA can inhibit cellular processes such as replication and transcription, which are vital for the proliferation of cells. By investigating how platinum complexes achieved these different interactions we may be able to determine the relationships between the structural characteristics, biophysical properties and biological activity in order to design more effective anticancer drugs.]]

Original language	English
Title of host publication	Supramolecular Systems in Biomedical Fields
Editors	Hans-Jörg Schneider
Place of Publication	U.K.
Publisher	Royal Society of Chemistry
ISBN (Electronic)	9781849737821
ISBN (Print)	9781849736589
Publication status	Published - 2013

Cite this

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title = "Biomolecular ineractions of platinum complexes",

abstract = "![CDATA[The in vitro and in vivo effects of platinum complexes have been well reported. However, it is their interactions with biologically relevant structures and bio-macromolecules such as DNA and proteins that can determine their therapeutic effects. The pharmacological properties of platinum complexes are dependent on binding interactions, and the investigation of such interactions is essential to gain insight into the mechanisms of action. Interactions with DNA can inhibit cellular processes such as replication and transcription, which are vital for the proliferation of cells. By investigating how platinum complexes achieved these different interactions we may be able to determine the relationships between the structural characteristics, biophysical properties and biological activity in order to design more effective anticancer drugs.]]",

author = "Harper, {Benjamin W.} and Feng Li and Rhys Beard and Garbutcheon-Singh, {K. Benjamin} and Ng, {Neville S.} and Aldrich-Wright, {Janice R.}",

year = "2013",

language = "English",

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editor = "Hans-J{\"o}rg Schneider",

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publisher = "Royal Society of Chemistry",

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TY - CHAP

T1 - Biomolecular ineractions of platinum complexes

AU - Harper, Benjamin W.

AU - Li, Feng

AU - Beard, Rhys

AU - Garbutcheon-Singh, K. Benjamin

AU - Ng, Neville S.

AU - Aldrich-Wright, Janice R.

PY - 2013

Y1 - 2013

N2 - ![CDATA[The in vitro and in vivo effects of platinum complexes have been well reported. However, it is their interactions with biologically relevant structures and bio-macromolecules such as DNA and proteins that can determine their therapeutic effects. The pharmacological properties of platinum complexes are dependent on binding interactions, and the investigation of such interactions is essential to gain insight into the mechanisms of action. Interactions with DNA can inhibit cellular processes such as replication and transcription, which are vital for the proliferation of cells. By investigating how platinum complexes achieved these different interactions we may be able to determine the relationships between the structural characteristics, biophysical properties and biological activity in order to design more effective anticancer drugs.]]

AB - ![CDATA[The in vitro and in vivo effects of platinum complexes have been well reported. However, it is their interactions with biologically relevant structures and bio-macromolecules such as DNA and proteins that can determine their therapeutic effects. The pharmacological properties of platinum complexes are dependent on binding interactions, and the investigation of such interactions is essential to gain insight into the mechanisms of action. Interactions with DNA can inhibit cellular processes such as replication and transcription, which are vital for the proliferation of cells. By investigating how platinum complexes achieved these different interactions we may be able to determine the relationships between the structural characteristics, biophysical properties and biological activity in order to design more effective anticancer drugs.]]

UR - http://handle.uws.edu.au:8081/1959.7/540203

M3 - Chapter

SN - 9781849736589

BT - Supramolecular Systems in Biomedical Fields

A2 - Schneider, Hans-Jörg

PB - Royal Society of Chemistry

CY - U.K.

ER -

Biomolecular ineractions of platinum complexes

Abstract

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