Calcium imaging in brain tissue slices

Orsolya Kékesi, Nisal Keembiyage, Yossi Buskila

Research output: Chapter in Book / Conference PaperChapterpeer-review

Abstract

Calcium imaging is a method that was first developed in the mid-1970s yet kept developing until current days to allow accurate measurement of free calcium ions in tissues. This widely used method has provided significant advances to our understanding of cellular signal transduction, including the discovery of subcellular compartmentalization of neurons and astrocytes, the identification of multiple signaling pathways, and mapping the functional connectivity between astrocytes and neuronal networks. Here we describe a method for the loading and imaging of cell-permeable AM ester calcium-sensitive dyes for the in vitro measurement of free intracellular Ca2+ ions in acute brain slices.
Original languageEnglish
Title of host publicationCalcium Signaling: Methods and Protocols
EditorsCaroline M. Gorvin
Place of PublicationU.S.
PublisherHumana Press
Chapter7
Pages89-96
Number of pages8
ISBN (Electronic)9781071641644
ISBN (Print)9781071641637
DOIs
Publication statusPublished - 2025

Publication series

NameMethods in Molecular Biology
Volume2861
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • AM dyes
  • Brain slices
  • Braincubator
  • Calcium imaging
  • Neurophysiology

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