Cancer is not (only) a senescence problem

Frédéric Thomas; Fabrice Vavre; Tazzio Tissot; Marion Vittecoq; Mathieu Giraudeau; Florence Bernex; Dorothée Misse; François Renaud; Nynke Raven; Christa Beckmann; Rodrigo Hamede; Peter A. Biro; Beata Ujvari

doi:10.1016/j.trecan.2018.01.002

Cancer is not (only) a senescence problem

Frédéric Thomas, Fabrice Vavre, Tazzio Tissot, Marion Vittecoq, Mathieu Giraudeau, Florence Bernex, Dorothée Misse, François Renaud, Nynke Raven, Christa Beckmann, Rodrigo Hamede, Peter A. Biro, Beata Ujvari

Western Sydney University

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Age is one of the strongest predictors of cancer and risk of death from cancer. Cancer is therefore generally viewed as a senescence-related malady. However, cancer also exists at subclinical levels in humans and other animals, but its earlier effects on the body are poorly known by comparison. We argue here that cancer is a significant but ignored burden on the body and is likely to be a strong selective force from early during the lifetime of an organism. It is time to adopt this novel view of malignant pathologies to improve our understanding of the ways in which oncogenic phenomena influence the ecology and evolution of animals long before their negative impacts become evident and fatal.

Original language	English
Pages (from-to)	169-172
Number of pages	4
Journal	Trends in Cancer
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.trecan.2018.01.002
Publication status	Published - 2018

Keywords

aging
cancer
oncogenes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trecan.2018.01.002

Cite this

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title = "Cancer is not (only) a senescence problem",

abstract = "Age is one of the strongest predictors of cancer and risk of death from cancer. Cancer is therefore generally viewed as a senescence-related malady. However, cancer also exists at subclinical levels in humans and other animals, but its earlier effects on the body are poorly known by comparison. We argue here that cancer is a significant but ignored burden on the body and is likely to be a strong selective force from early during the lifetime of an organism. It is time to adopt this novel view of malignant pathologies to improve our understanding of the ways in which oncogenic phenomena influence the ecology and evolution of animals long before their negative impacts become evident and fatal.",

keywords = "aging, cancer, oncogenes",

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doi = "10.1016/j.trecan.2018.01.002",

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TY - JOUR

T1 - Cancer is not (only) a senescence problem

AU - Thomas, Frédéric

AU - Vavre, Fabrice

AU - Tissot, Tazzio

AU - Vittecoq, Marion

AU - Giraudeau, Mathieu

AU - Bernex, Florence

AU - Misse, Dorothée

AU - Renaud, François

AU - Raven, Nynke

AU - Beckmann, Christa

AU - Hamede, Rodrigo

AU - Biro, Peter A.

AU - Ujvari, Beata

PY - 2018

Y1 - 2018

N2 - Age is one of the strongest predictors of cancer and risk of death from cancer. Cancer is therefore generally viewed as a senescence-related malady. However, cancer also exists at subclinical levels in humans and other animals, but its earlier effects on the body are poorly known by comparison. We argue here that cancer is a significant but ignored burden on the body and is likely to be a strong selective force from early during the lifetime of an organism. It is time to adopt this novel view of malignant pathologies to improve our understanding of the ways in which oncogenic phenomena influence the ecology and evolution of animals long before their negative impacts become evident and fatal.

AB - Age is one of the strongest predictors of cancer and risk of death from cancer. Cancer is therefore generally viewed as a senescence-related malady. However, cancer also exists at subclinical levels in humans and other animals, but its earlier effects on the body are poorly known by comparison. We argue here that cancer is a significant but ignored burden on the body and is likely to be a strong selective force from early during the lifetime of an organism. It is time to adopt this novel view of malignant pathologies to improve our understanding of the ways in which oncogenic phenomena influence the ecology and evolution of animals long before their negative impacts become evident and fatal.

KW - aging

KW - cancer

KW - oncogenes

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:49039

U2 - 10.1016/j.trecan.2018.01.002

DO - 10.1016/j.trecan.2018.01.002

M3 - Article

SN - 2405-8025

VL - 4

SP - 169

EP - 172

JO - Trends in Cancer

JF - Trends in Cancer

IS - 3

ER -

Cancer is not (only) a senescence problem

Abstract

Keywords

UN SDGs

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