Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History Evolution

Antoine M. Dujon; Justine Boutry; Sophie Tissot; Jean-François Lemaître; Amy M. Boddy; Anne-Lise Gérard; Alexandra Alvergne; Audrey Arnal; Orsolya Vincze; Delphine Nicolas; Mathieu Giraudeau; Marina Telonis-Scott; Aaron Schultz; Pascal Pujol; Peter A. Biro; Christa Beckmann; Rodrigo Hamede; Benjamin Roche; Beata Ujvari; Frédéric Thomas

doi:10.3389/fevo.2022.861103

Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History Evolution

Antoine M. Dujon, Justine Boutry, Sophie Tissot, Jean-François Lemaître, Amy M. Boddy, Anne-Lise Gérard, Alexandra Alvergne, Audrey Arnal, Orsolya Vincze, Delphine Nicolas, Mathieu Giraudeau, Marina Telonis-Scott, Aaron Schultz, Pascal Pujol, Peter A. Biro, Christa Beckmann, Rodrigo Hamede, Benjamin Roche, Beata Ujvari, Frédéric Thomas

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Reproduction is one of the most energetically demanding life-history stages. As a result, breeding individuals often experience trade-offs, where energy is diverted away from maintenance (cell repair, immune function) toward reproduction. While it is increasingly acknowledged that oncogenic processes are omnipresent, evolving and opportunistic entities in the bodies of metazoans, the associations among reproductive activities, energy expenditure, and the dynamics of malignant cells have rarely been studied. Here, we review the diverse ways in which age-specific reproductive performance (e.g., reproductive aging patterns) and cancer risks throughout the life course may be linked via trade-offs or other mechanisms, as well as discuss situations where trade-offs may not exist. We argue that the interactions between host–oncogenic processes should play a significant role in life-history theory, and suggest some avenues for future research.

Original language	English
Article number	861103
Number of pages	18
Journal	Frontiers in Ecology and Evolution
Volume	10
DOIs	https://doi.org/10.3389/fevo.2022.861103
Publication status	Published - 9 May 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Dujon, Boutry, Tissot, Lemaître, Boddy, Gérard, Alvergne, Arnal, Vincze, Nicolas, Giraudeau, Telonis-Scott, Schultz, Pujol, Biro, Beckmann, Hamede, Roche, Ujvari and Thomas.

Open Access - Access Right Statement

© 2022 Dujon, Boutry, Tissot, Lemaître, Boddy, Gérard, Alvergne, Arnal, Vincze, Nicolas, Giraudeau, Telonis-Scott, Schultz, Pujol, Biro, Beckmann, Hamede, Roche, Ujvari and Thomas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fevo.2022.861103

Open Access

Cite this

Dujon, A. M., Boutry, J., Tissot, S., Lemaître, J.-F., Boddy, A. M., Gérard, A.-L., Alvergne, A., Arnal, A., Vincze, O., Nicolas, D., Giraudeau, M., Telonis-Scott, M., Schultz, A., Pujol, P., Biro, P. A., Beckmann, C., Hamede, R., Roche, B., Ujvari, B., & Thomas, F. (2022). Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History Evolution. Frontiers in Ecology and Evolution, 10, Article 861103. https://doi.org/10.3389/fevo.2022.861103

@article{1681182378ba4b40abfafec385bd561f,

title = "Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History Evolution",

abstract = "Reproduction is one of the most energetically demanding life-history stages. As a result, breeding individuals often experience trade-offs, where energy is diverted away from maintenance (cell repair, immune function) toward reproduction. While it is increasingly acknowledged that oncogenic processes are omnipresent, evolving and opportunistic entities in the bodies of metazoans, the associations among reproductive activities, energy expenditure, and the dynamics of malignant cells have rarely been studied. Here, we review the diverse ways in which age-specific reproductive performance (e.g., reproductive aging patterns) and cancer risks throughout the life course may be linked via trade-offs or other mechanisms, as well as discuss situations where trade-offs may not exist. We argue that the interactions between host–oncogenic processes should play a significant role in life-history theory, and suggest some avenues for future research.",

author = "Dujon, {Antoine M.} and Justine Boutry and Sophie Tissot and Jean-Fran{\c c}ois Lema{\^i}tre and Boddy, {Amy M.} and Anne-Lise G{\'e}rard and Alexandra Alvergne and Audrey Arnal and Orsolya Vincze and Delphine Nicolas and Mathieu Giraudeau and Marina Telonis-Scott and Aaron Schultz and Pascal Pujol and Biro, {Peter A.} and Christa Beckmann and Rodrigo Hamede and Benjamin Roche and Beata Ujvari and Fr{\'e}d{\'e}ric Thomas",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Dujon, Boutry, Tissot, Lema{\^i}tre, Boddy, G{\'e}rard, Alvergne, Arnal, Vincze, Nicolas, Giraudeau, Telonis-Scott, Schultz, Pujol, Biro, Beckmann, Hamede, Roche, Ujvari and Thomas.",

year = "2022",

month = may,

day = "9",

doi = "10.3389/fevo.2022.861103",

language = "English",

volume = "10",

journal = "Frontiers in Ecology and Evolution",

issn = "2296-701X",

publisher = "Frontiers Media SA",

}

Dujon, AM, Boutry, J, Tissot, S, Lemaître, J-F, Boddy, AM, Gérard, A-L, Alvergne, A, Arnal, A, Vincze, O, Nicolas, D, Giraudeau, M, Telonis-Scott, M, Schultz, A, Pujol, P, Biro, PA, Beckmann, C, Hamede, R, Roche, B, Ujvari, B & Thomas, F 2022, 'Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History Evolution', Frontiers in Ecology and Evolution, vol. 10, 861103. https://doi.org/10.3389/fevo.2022.861103

TY - JOUR

T1 - Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History Evolution

AU - Dujon, Antoine M.

AU - Boutry, Justine

AU - Tissot, Sophie

AU - Lemaître, Jean-François

AU - Boddy, Amy M.

AU - Gérard, Anne-Lise

AU - Alvergne, Alexandra

AU - Arnal, Audrey

AU - Vincze, Orsolya

AU - Nicolas, Delphine

AU - Giraudeau, Mathieu

AU - Telonis-Scott, Marina

AU - Schultz, Aaron

AU - Pujol, Pascal

AU - Biro, Peter A.

AU - Beckmann, Christa

AU - Hamede, Rodrigo

AU - Roche, Benjamin

AU - Ujvari, Beata

AU - Thomas, Frédéric

N1 - Publisher Copyright: Copyright © 2022 Dujon, Boutry, Tissot, Lemaître, Boddy, Gérard, Alvergne, Arnal, Vincze, Nicolas, Giraudeau, Telonis-Scott, Schultz, Pujol, Biro, Beckmann, Hamede, Roche, Ujvari and Thomas.

PY - 2022/5/9

Y1 - 2022/5/9

N2 - Reproduction is one of the most energetically demanding life-history stages. As a result, breeding individuals often experience trade-offs, where energy is diverted away from maintenance (cell repair, immune function) toward reproduction. While it is increasingly acknowledged that oncogenic processes are omnipresent, evolving and opportunistic entities in the bodies of metazoans, the associations among reproductive activities, energy expenditure, and the dynamics of malignant cells have rarely been studied. Here, we review the diverse ways in which age-specific reproductive performance (e.g., reproductive aging patterns) and cancer risks throughout the life course may be linked via trade-offs or other mechanisms, as well as discuss situations where trade-offs may not exist. We argue that the interactions between host–oncogenic processes should play a significant role in life-history theory, and suggest some avenues for future research.

AB - Reproduction is one of the most energetically demanding life-history stages. As a result, breeding individuals often experience trade-offs, where energy is diverted away from maintenance (cell repair, immune function) toward reproduction. While it is increasingly acknowledged that oncogenic processes are omnipresent, evolving and opportunistic entities in the bodies of metazoans, the associations among reproductive activities, energy expenditure, and the dynamics of malignant cells have rarely been studied. Here, we review the diverse ways in which age-specific reproductive performance (e.g., reproductive aging patterns) and cancer risks throughout the life course may be linked via trade-offs or other mechanisms, as well as discuss situations where trade-offs may not exist. We argue that the interactions between host–oncogenic processes should play a significant role in life-history theory, and suggest some avenues for future research.

UR - https://hdl.handle.net/1959.7/uws:66177

U2 - 10.3389/fevo.2022.861103

DO - 10.3389/fevo.2022.861103

M3 - Article

SN - 2296-701X

VL - 10

JO - Frontiers in Ecology and Evolution

JF - Frontiers in Ecology and Evolution

M1 - 861103

ER -

Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History Evolution

Abstract

Bibliographical note

Open Access - Access Right Statement

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this