Cannabis abuse and dependence

Tim Karl, Jonathon C. Arnold

Research output: Chapter in Book / Conference PaperChapter

Abstract

Cannabis is the most widely used illicit drug in the world; however, only a small proportion of people who experiment with cannabis develop an addiction to it. Genetic predisposition plays a role in vulnerability to marijuana addiction and human and animal research has begun uncovering the specific genes involved. This chapter will discuss how genetic mouse models (inbred strains as well as mouse models for gene candidates) have deepened our understanding of the development of cannabis abuse and cannabis dependence (for definition see “Cannabis abuse and dependence” below) and the mechanism involved. We will first outline the main characteristics of the endocannabinoid system, cannabis abuse and dependence in humans, and the experimental animal models that measure the addictive and reinforcing properties of cannabis. Following this we will explore the non-specific genetic factors that might be involved in the occurrence of cannabis abuse and the development of cannabis dependence (insights from both mouse and rat research will be considered). We will consider gene candidates, which have been suggested by linkage and association studies, and evaluate biological targets potentially relevant for the cannabinoid system and drug dependence. Finally, we will outline how genetic mouse model research has been critical in understanding the role of those genes/targets in the cannabinoid system and the development of cannabis use disorder (which is defined as cannabis abuse and dependence).
Original languageEnglish
Title of host publicationBehavioral Genetics of the Mouse. Vol. 2, Genetic Mouse Models of Neurobehavioural Disorders
EditorsSusanna Pietropaolo, Frans Sluyter, Wim E. Crusio
Place of PublicationUnited Kingdom
PublisherCambridge University Press
Pages315-329
Number of pages15
ISBN (Electronic)9781316075579
ISBN (Print)9781107044456
Publication statusPublished - 2014

Keywords

  • cannabinoids
  • genetics
  • marijuana abuse

Fingerprint

Dive into the research topics of 'Cannabis abuse and dependence'. Together they form a unique fingerprint.

Cite this