Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus

Clarence J. Fernandes; Lorna A. Fernandes; Peter Collignon; Susan Bradbury; Thomas Gottlieb; Glenn Funnell; Sue Tiley; Ian Winney; James Branley; Sam Ryder; Iain B. Gosbell; Helen Ziochos; Alistair McGregor; Rob Peterson; David Mitchell

doi:10.1093/jac/dki052

Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus

Clarence J. Fernandes, Lorna A. Fernandes, Peter Collignon, Susan Bradbury, Thomas Gottlieb, Glenn Funnell, Sue Tiley, Ian Winney, James Branley, Sam Ryder, Iain B. Gosbell, Helen Ziochos, Alistair McGregor, Rob Peterson, David Mitchell

Research output: Contribution to journal › Article › peer-review

113 Citations (Scopus)

Abstract

Objectives: To evaluate the usefulness of cefoxitin when used as a surrogate marker for the detection of methicillin resistance. Patients and methods: Eight hundred and seventy-one strains of Staphylococcus aureus, collected from eight tertiary referral centres serving diverse socio-economic populations, were included in the study using NCCLS disc diffusion and the agar dilution methods. Results: Using cefoxitin and NCCLS criteria for disc diffusion, the sensitivity and specificity for recognizing methicillin resistance were both 100%. Similar results were obtained when the strains were tested by the agar dilution method. The cefoxitin MICs for methicillin-susceptible strains were ≤ 4 mg/L. Conclusions: Testing with cefoxitin as a surrogate marker for the detection of methicillin resistance was very accurate with both disc diffusion and agar dilution methods. Such testing clearly distinguished methicillin-resistant strains of S. aureus from methicillin-susceptible strains.

Original language	English
Pages (from-to)	506-510
Number of pages	5
Journal	Journal of Antimicrobial Chemotherapy
Volume	55
Issue number	4
DOIs	https://doi.org/10.1093/jac/dki052
Publication status	Published - Apr 2005
Externally published	Yes

Keywords

Community-onset MRSA infections
Hospital-acquired infections
Non-multiresistant staphylococcus aureus
Oxacillin resistance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Fernandes, C. J., Fernandes, L. A., Collignon, P., Bradbury, S., Gottlieb, T., Funnell, G., Tiley, S., Winney, I., Branley, J., Ryder, S., Gosbell, I. B., Ziochos, H., McGregor, A., Peterson, R., & Mitchell, D. (2005). Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 55(4), 506-510. https://doi.org/10.1093/jac/dki052

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title = "Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus",

abstract = "Objectives: To evaluate the usefulness of cefoxitin when used as a surrogate marker for the detection of methicillin resistance. Patients and methods: Eight hundred and seventy-one strains of Staphylococcus aureus, collected from eight tertiary referral centres serving diverse socio-economic populations, were included in the study using NCCLS disc diffusion and the agar dilution methods. Results: Using cefoxitin and NCCLS criteria for disc diffusion, the sensitivity and specificity for recognizing methicillin resistance were both 100%. Similar results were obtained when the strains were tested by the agar dilution method. The cefoxitin MICs for methicillin-susceptible strains were ≤ 4 mg/L. Conclusions: Testing with cefoxitin as a surrogate marker for the detection of methicillin resistance was very accurate with both disc diffusion and agar dilution methods. Such testing clearly distinguished methicillin-resistant strains of S. aureus from methicillin-susceptible strains.",

keywords = "Community-onset MRSA infections, Hospital-acquired infections, Non-multiresistant staphylococcus aureus, Oxacillin resistance",

author = "Fernandes, {Clarence J.} and Fernandes, {Lorna A.} and Peter Collignon and Susan Bradbury and Thomas Gottlieb and Glenn Funnell and Sue Tiley and Ian Winney and James Branley and Sam Ryder and Gosbell, {Iain B.} and Helen Ziochos and Alistair McGregor and Rob Peterson and David Mitchell",

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doi = "10.1093/jac/dki052",

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Fernandes, CJ, Fernandes, LA, Collignon, P, Bradbury, S, Gottlieb, T, Funnell, G, Tiley, S, Winney, I, Branley, J, Ryder, S, Gosbell, IB, Ziochos, H, McGregor, A, Peterson, R & Mitchell, D 2005, 'Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus', Journal of Antimicrobial Chemotherapy, vol. 55, no. 4, pp. 506-510. https://doi.org/10.1093/jac/dki052

TY - JOUR

T1 - Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus

AU - Fernandes, Clarence J.

AU - Fernandes, Lorna A.

AU - Collignon, Peter

AU - Bradbury, Susan

AU - Gottlieb, Thomas

AU - Funnell, Glenn

AU - Tiley, Sue

AU - Winney, Ian

AU - Branley, James

AU - Ryder, Sam

AU - Gosbell, Iain B.

AU - Ziochos, Helen

AU - McGregor, Alistair

AU - Peterson, Rob

AU - Mitchell, David

PY - 2005/4

Y1 - 2005/4

N2 - Objectives: To evaluate the usefulness of cefoxitin when used as a surrogate marker for the detection of methicillin resistance. Patients and methods: Eight hundred and seventy-one strains of Staphylococcus aureus, collected from eight tertiary referral centres serving diverse socio-economic populations, were included in the study using NCCLS disc diffusion and the agar dilution methods. Results: Using cefoxitin and NCCLS criteria for disc diffusion, the sensitivity and specificity for recognizing methicillin resistance were both 100%. Similar results were obtained when the strains were tested by the agar dilution method. The cefoxitin MICs for methicillin-susceptible strains were ≤ 4 mg/L. Conclusions: Testing with cefoxitin as a surrogate marker for the detection of methicillin resistance was very accurate with both disc diffusion and agar dilution methods. Such testing clearly distinguished methicillin-resistant strains of S. aureus from methicillin-susceptible strains.

AB - Objectives: To evaluate the usefulness of cefoxitin when used as a surrogate marker for the detection of methicillin resistance. Patients and methods: Eight hundred and seventy-one strains of Staphylococcus aureus, collected from eight tertiary referral centres serving diverse socio-economic populations, were included in the study using NCCLS disc diffusion and the agar dilution methods. Results: Using cefoxitin and NCCLS criteria for disc diffusion, the sensitivity and specificity for recognizing methicillin resistance were both 100%. Similar results were obtained when the strains were tested by the agar dilution method. The cefoxitin MICs for methicillin-susceptible strains were ≤ 4 mg/L. Conclusions: Testing with cefoxitin as a surrogate marker for the detection of methicillin resistance was very accurate with both disc diffusion and agar dilution methods. Such testing clearly distinguished methicillin-resistant strains of S. aureus from methicillin-susceptible strains.

KW - Community-onset MRSA infections

KW - Hospital-acquired infections

KW - Non-multiresistant staphylococcus aureus

KW - Oxacillin resistance

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AN - SCOPUS:20244388509

SN - 0305-7453

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JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 4

ER -

Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus

Abstract

Keywords

UN SDGs

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