Cell-specific modeling of retinal ganglion cell electrical activity

Tianruo Guo; David Tsai; John W. Morley; Gregg J. Suaning; Nigel H. Lovell; Socrates Dokos

doi:10.1109/EMBC.2013.6611053

Cell-specific modeling of retinal ganglion cell electrical activity

Tianruo Guo, David Tsai, John W. Morley, Gregg J. Suaning, Nigel H. Lovell, Socrates Dokos

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

13 Citations (Scopus)

Abstract

![CDATA[Variations in ionic channel expression and anatomical properties can influence how different retinal ganglion cell (RGC) types process synaptic information. Computational modeling approaches allow us to precisely control these biophysical and physical properties and isolate their effects in shaping RGC firing patterns. In this study, three models based on realistic representations of RGC morphologies were used to simulate the contribution of spatial structure of neurons and membrane ion channel properties to RGC electrical activity. In all simulations, the RGC models shared common ionic channel kinetics, differing only in their regional ionic channel distributions and cell morphology.]]

Original language	English
Title of host publication	Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan
Publisher	IEEE
Pages	6539-6542
Number of pages	4
ISBN (Print)	9781457702167
DOIs	https://doi.org/10.1109/EMBC.2013.6611053
Publication status	Published - 2013
Event	IEEE Engineering in Medicine and Biology Society. Conference - Duration: 3 Jul 2013 → …

Publication series

Name
ISSN (Print)	1557-170X

Conference

Conference	IEEE Engineering in Medicine and Biology Society. Conference
Period	3/07/13 → …

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10.1109/EMBC.2013.6611053

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Guo, T., Tsai, D., Morley, J. W., Suaning, G. J., Lovell, N. H., & Dokos, S. (2013). Cell-specific modeling of retinal ganglion cell electrical activity. In Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan (pp. 6539-6542). IEEE. https://doi.org/10.1109/EMBC.2013.6611053

@inproceedings{b2dd5645e411475c81cc97bffabd5e82,

title = "Cell-specific modeling of retinal ganglion cell electrical activity",

abstract = "![CDATA[Variations in ionic channel expression and anatomical properties can influence how different retinal ganglion cell (RGC) types process synaptic information. Computational modeling approaches allow us to precisely control these biophysical and physical properties and isolate their effects in shaping RGC firing patterns. In this study, three models based on realistic representations of RGC morphologies were used to simulate the contribution of spatial structure of neurons and membrane ion channel properties to RGC electrical activity. In all simulations, the RGC models shared common ionic channel kinetics, differing only in their regional ionic channel distributions and cell morphology.]]",

author = "Tianruo Guo and David Tsai and Morley, {John W.} and Suaning, {Gregg J.} and Lovell, {Nigel H.} and Socrates Dokos",

year = "2013",

doi = "10.1109/EMBC.2013.6611053",

language = "English",

isbn = "9781457702167",

publisher = "IEEE",

pages = "6539--6542",

booktitle = "Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan",

note = "IEEE Engineering in Medicine and Biology Society. Conference ; Conference date: 03-07-2013",

}

Guo, T, Tsai, D, Morley, JW, Suaning, GJ, Lovell, NH & Dokos, S 2013, Cell-specific modeling of retinal ganglion cell electrical activity. in Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan. IEEE, pp. 6539-6542, IEEE Engineering in Medicine and Biology Society. Conference, 3/07/13. https://doi.org/10.1109/EMBC.2013.6611053

Cell-specific modeling of retinal ganglion cell electrical activity. / Guo, Tianruo; Tsai, David; Morley, John W. et al.
Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan. IEEE, 2013. p. 6539-6542.

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

TY - GEN

T1 - Cell-specific modeling of retinal ganglion cell electrical activity

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AU - Lovell, Nigel H.

AU - Dokos, Socrates

PY - 2013

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AB - ![CDATA[Variations in ionic channel expression and anatomical properties can influence how different retinal ganglion cell (RGC) types process synaptic information. Computational modeling approaches allow us to precisely control these biophysical and physical properties and isolate their effects in shaping RGC firing patterns. In this study, three models based on realistic representations of RGC morphologies were used to simulate the contribution of spatial structure of neurons and membrane ion channel properties to RGC electrical activity. In all simulations, the RGC models shared common ionic channel kinetics, differing only in their regional ionic channel distributions and cell morphology.]]

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PB - IEEE

T2 - IEEE Engineering in Medicine and Biology Society. Conference

Y2 - 3 July 2013

ER -

Cell-specific modeling of retinal ganglion cell electrical activity

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