Cell-specific modeling of retinal ganglion cell electrical activity

Tianruo Guo, David Tsai, John W. Morley, Gregg J. Suaning, Nigel H. Lovell, Socrates Dokos

Research output: Chapter in Book / Conference PaperConference Paperpeer-review

14 Citations (Scopus)

Abstract

Variations in ionic channel expression and anatomical properties can influence how different retinal ganglion cell (RGC) types process synaptic information. Computational modeling approaches allow us to precisely control these biophysical and physical properties and isolate their effects in shaping RGC firing patterns. In this study, three models based on realistic representations of RGC morphologies were used to simulate the contribution of spatial structure of neurons and membrane ion channel properties to RGC electrical activity. In all simulations, the RGC models shared common ionic channel kinetics, differing only in their regional ionic channel distributions and cell morphology.
Original languageEnglish
Title of host publicationProceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan
PublisherIEEE
Pages6539-6542
Number of pages4
ISBN (Print)9781457702167
DOIs
Publication statusPublished - 2013
EventIEEE Engineering in Medicine and Biology Society. Conference -
Duration: 3 Jul 2013 → …

Publication series

Name
ISSN (Print)1557-170X

Conference

ConferenceIEEE Engineering in Medicine and Biology Society. Conference
Period3/07/13 → …

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